# OnCo record prmt5-mtap (target). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)". Whole corpus: https://onco.cc/api/v1/onco.nt
@prefix schema: <https://schema.org/> .
@prefix onco: <https://onco.cc/ns#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .

<https://onco.cc/targets/prmt5-mtap/>
  a schema:BioChemEntity ;
  onco:kind "target" ;
  schema:identifier "prmt5-mtap" ;
  schema:name "PRMT5 (MTAP-deleted cancers)"@en ;
  schema:description "An enzyme that cancers lacking the MTAP gene (about 10-15% of all tumours) depend on more than normal cells do; new inhibitors designed to exploit that difference are in late trials."@en ;
  schema:url <https://onco.cc/targets/prmt5-mtap/> ;
  schema:dateModified "2026-09-08"^^xsd:date ;
  schema:sameAs <https://en.wikipedia.org/wiki/PRMT5>, <https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:10894>, <https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000100462>, <https://www.uniprot.org/uniprotkb/O14744/entry>, <https://www.ncbi.nlm.nih.gov/gene/10419> ;
  schema:citation <https://doi.org/10.1158/2159-8290.CD-23-0669> ;
  onco:tag "gap-fill" ;
  schema:alternateName "PRMT5" ;
  onco:targetClass "enzyme" ;
  onco:firstDescribed "1998"^^xsd:gYear ;
  onco:cancers <https://onco.cc/cancers/mesothelioma/>, <https://onco.cc/cancers/glioblastoma/>, <https://onco.cc/cancers/pancreatic/>, <https://onco.cc/cancers/nsclc/>, <https://onco.cc/cancers/urothelial/>, <https://onco.cc/cancers/cholangiocarcinoma/> ;
  onco:technologies <https://onco.cc/technologies/synthetic-lethality-approaches/>, <https://onco.cc/technologies/cgp/>, <https://onco.cc/technologies/cancer-cell-line-encyclopedias/> ;
  onco:drugs <https://onco.cc/drugs/navlimetostat/>, <https://onco.cc/drugs/tng462/>, <https://onco.cc/drugs/azd3470/>, <https://onco.cc/drugs/anvumetostat/>, <https://onco.cc/drugs/tng456/> ;
  onco:companies <https://onco.cc/companies/amgen/>, <https://onco.cc/companies/bms/>, <https://onco.cc/companies/astrazeneca/> ;
  onco:terms <https://onco.cc/terms/synthetic-lethality/> ;
  onco:keyPapers <https://onco.cc/key-papers/paper-engstrom-cancer-discov/> .