# OnCo record profile-1014 (trial). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)". Whole corpus: https://onco.cc/api/v1/onco.nt
@prefix schema: <https://schema.org/> .
@prefix onco: <https://onco.cc/ns#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .

<https://onco.cc/trials/profile-1014/>
  a schema:MedicalTrial ;
  onco:kind "trial" ;
  schema:identifier "profile-1014", "NCT01154140" ;
  schema:name "PROFILE 1014"@en ;
  schema:description "The trial that made an ALK pill, rather than chemotherapy, the first treatment for ALK-positive lung cancer."@en ;
  schema:url <https://onco.cc/trials/profile-1014/> ;
  schema:dateModified "2026-09-25"^^xsd:date ;
  schema:citation <https://clinicaltrials.gov/study/NCT01154140>, <https://doi.org/10.1056/NEJMoa1408440> ;
  onco:status "positive" ;
  onco:phase "3" ;
  onco:cancers <https://onco.cc/cancers/alk-positive-nsclc/> ;
  onco:technologies <https://onco.cc/technologies/kinase-inhibitors/>, <https://onco.cc/technologies/cytotoxic-chemotherapy/>, <https://onco.cc/technologies/platinum/> ;
  onco:targets <https://onco.cc/targets/alk/> ;
  onco:drugs <https://onco.cc/drugs/crizotinib/>, <https://onco.cc/drugs/pemetrexed/>, <https://onco.cc/drugs/cisplatin/>, <https://onco.cc/drugs/carboplatin/> ;
  onco:companies <https://onco.cc/companies/pfizer/> ;
  onco:terms <https://onco.cc/terms/gene-fusion/>, <https://onco.cc/terms/oncogene-addiction/>, <https://onco.cc/terms/tki-term/> ;
  onco:trials <https://onco.cc/trials/alex/>, <https://onco.cc/trials/alta-1l/>, <https://onco.cc/trials/crown/>, <https://onco.cc/trials/alesia/> .