# OnCo record project-optimus (term). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)". Whole corpus: https://onco.cc/api/v1/onco.nt
@prefix schema: <https://schema.org/> .
@prefix onco: <https://onco.cc/ns#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .

<https://onco.cc/terms/project-optimus/>
  a schema:DefinedTerm ;
  onco:kind "term" ;
  schema:identifier "project-optimus" ;
  schema:name "Project Optimus"@en ;
  schema:alternateName "Optimus"@en, "FDA dose optimisation initiative"@en, "dose optimisation guidance"@en, "randomised dose-optimisation"@en, "randomized dose-optimization"@en, "dose-optimisation cohort"@en, "dose-optimization cohort"@en, "two-dose randomisation"@en, "exposure-response"@en, "exposure-response analysis"@en ;
  schema:description "An FDA programme pushing companies to find the best dose of a cancer drug, not just the highest tolerable one."@en ;
  schema:url <https://onco.cc/terms/project-optimus/> ;
  schema:dateModified "2026-09-08"^^xsd:date ;
  schema:citation <https://www.fda.gov/about-fda/oncology-center-excellence/project-optimus> ;
  onco:related <https://onco.cc/terms/dose-escalation-design/>, <https://onco.cc/terms/mtd/>, <https://onco.cc/terms/rp2d/>, <https://onco.cc/terms/dose-limiting-toxicity/>, <https://onco.cc/terms/seamless-adaptive/>, <https://onco.cc/terms/bayesian-trial-design/>, <https://onco.cc/terms/qol-pro/> ;
  onco:technologies <https://onco.cc/technologies/kinase-inhibitors/>, <https://onco.cc/technologies/adc/> ;
  onco:drugs <https://onco.cc/drugs/sotorasib/> ;
  onco:trials <https://onco.cc/trials/rejoice-ovarian01/>, <https://onco.cc/trials/low-dose-nivolumab-tmh/> .