# OnCo record proteasome (target). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)". Whole corpus: https://onco.cc/api/v1/onco.nt
@prefix schema: <https://schema.org/> .
@prefix onco: <https://onco.cc/ns#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .

<https://onco.cc/targets/proteasome/>
  a schema:BioChemEntity ;
  onco:kind "target" ;
  schema:identifier "proteasome" ;
  schema:name "Proteasome (PSMB5)"@en ;
  schema:description "The cell's protein shredder. Myeloma cells make huge amounts of antibody protein and depend on the proteasome to clear the waste, so blocking it kills them."@en ;
  schema:url <https://onco.cc/targets/proteasome/> ;
  schema:dateModified "2026-09-04"^^xsd:date ;
  schema:sameAs <https://en.wikipedia.org/wiki/Proteasome>, <https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:9542>, <https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000100804>, <https://www.uniprot.org/uniprotkb/P28074/entry>, <https://www.ncbi.nlm.nih.gov/gene/5693> ;
  schema:citation <https://www.uniprot.org/uniprotkb/P28074/entry> ;
  schema:alternateName "PSMB5" ;
  onco:targetClass "enzyme" ;
  onco:firstDescribed "1990"^^xsd:gYear ;
  onco:cancers <https://onco.cc/cancers/multiple-myeloma/>, <https://onco.cc/cancers/mantle-cell-lymphoma/> ;
  onco:drugs <https://onco.cc/drugs/bortezomib/>, <https://onco.cc/drugs/carfilzomib/> .