# OnCo record ptch1 (target). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)". Whole corpus: https://onco.cc/api/v1/onco.nt
@prefix schema: <https://schema.org/> .
@prefix onco: <https://onco.cc/ns#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .

<https://onco.cc/targets/ptch1/>
  a schema:BioChemEntity ;
  onco:kind "target" ;
  schema:identifier "ptch1" ;
  schema:name "PTCH1 (Patched 1)"@en ;
  schema:alternateName "Patched 1"@en, "PTCH"@en, "NBCCS"@en, "patched 1"@en, "PTCH1" ;
  schema:description "PTCH1 is the brake on the hedgehog growth pathway. When it is lost, as in nearly all basal cell carcinomas and in Gorlin syndrome, the pathway runs unchecked; vismodegib and sonidegib put the brake back one step down, at smoothened."@en ;
  schema:url <https://onco.cc/targets/ptch1/> ;
  schema:dateModified "2026-09-22"^^xsd:date ;
  schema:citation <https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:9585>, <https://www.uniprot.org/uniprotkb/Q13635/entry>, <https://www.ncbi.nlm.nih.gov/gene/5727> ;
  onco:tag "wave5-target" ;
  onco:targetClass "tumor-suppressor" ;
  schema:sameAs <https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:9585>, <https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000185920>, <https://www.uniprot.org/uniprotkb/Q13635/entry>, <https://www.ncbi.nlm.nih.gov/gene/5727> ;
  onco:related <https://onco.cc/drugs/vismodegib/>, <https://onco.cc/drugs/sonidegib/>, <https://onco.cc/drugs/patidegib/>, <https://onco.cc/targets/smoothened/> ;
  onco:cancers <https://onco.cc/cancers/basal-cell-carcinoma/>, <https://onco.cc/cancers/locally-advanced-bcc/>, <https://onco.cc/cancers/medulloblastoma-shh/> ;
  onco:technologies <https://onco.cc/technologies/hedgehog-inhibitors/> ;
  onco:pathways <https://onco.cc/pathways/hedgehog/>, <https://onco.cc/pathways/basal-cell-carcinoma-signalling/> .