# OnCo record pten-loss (term). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)". Whole corpus: https://onco.cc/api/v1/onco.nt
@prefix schema: <https://schema.org/> .
@prefix onco: <https://onco.cc/ns#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .

<https://onco.cc/terms/pten-loss/>
  a schema:DefinedTerm ;
  onco:kind "term" ;
  schema:identifier "pten-loss" ;
  schema:name "PTEN loss"@en ;
  schema:alternateName "PTEN"@en, "PTEN mutation"@en, "PTEN deletion"@en, "PTEN-deficient"@en, "PTEN-null"@en, "PTEN alteration"@en, "PTEN immunohistochemistry"@en, "PTEN loss by IHC"@en, "PTEN-altered"@en, "PIK3CA/AKT1/PTEN alterations"@en, "PI3K pathway alteration"@en, "AKT pathway alteration"@en, "Cowden syndrome"@en, "PTEN hamartoma tumour syndrome"@en ;
  schema:description "PTEN is the brake on the PI3K/AKT growth pathway; when a tumour deletes or mutates it (seen as a lost stain or on sequencing) the pathway runs unopposed. In hormone-treated breast cancer PTEN loss is one of the three changes that qualify a woman for capivasertib, in prostate cancer it marks aggressive disease, and in endometrial cancer it is almost universal in the NSMP group."@en ;
  schema:url <https://onco.cc/terms/pten-loss/> ;
  schema:dateModified "2026-09-17"^^xsd:date ;
  schema:sameAs <https://en.wikipedia.org/wiki/PTEN_(gene)> ;
  schema:citation <https://en.wikipedia.org/wiki/PTEN_(gene)> ;
  onco:related <https://onco.cc/targets/pik3ca/>, <https://onco.cc/targets/akt/>, <https://onco.cc/drugs/capivasertib/>, <https://onco.cc/drugs/alpelisib/>, <https://onco.cc/drugs/inavolisib/>, <https://onco.cc/drugs/everolimus/>, <https://onco.cc/terms/ihc/>, <https://onco.cc/terms/ngs/>, <https://onco.cc/terms/hereditary-cancer-syndromes/>, <https://onco.cc/terms/nsmp/> ;
  onco:cancers <https://onco.cc/cancers/breast-hr-positive/>, <https://onco.cc/cancers/hr-positive-metastatic-post-cdk46/>, <https://onco.cc/cancers/prostate-mhspc/>, <https://onco.cc/cancers/prostate-mcrpc/>, <https://onco.cc/cancers/endometrial-nsmp/>, <https://onco.cc/cancers/chromophobe-rcc/> .