# OnCo record pten (target). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)". Whole corpus: https://onco.cc/api/v1/onco.nt
@prefix schema: <https://schema.org/> .
@prefix onco: <https://onco.cc/ns#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .

<https://onco.cc/targets/pten/>
  a schema:BioChemEntity ;
  onco:kind "target" ;
  schema:identifier "pten" ;
  schema:name "PTEN"@en ;
  schema:alternateName "phosphatase and tensin homolog"@en, "MMAC1"@en, "TEP1"@en, "PTEN" ;
  schema:description "PTEN is the brake on the PI3K growth pathway; when a tumour loses it the pathway runs unchecked, which is why PTEN loss now selects patients for the AKT inhibitor capivasertib."@en ;
  schema:url <https://onco.cc/targets/pten/> ;
  schema:dateModified "2026-09-23"^^xsd:date ;
  schema:sameAs <https://en.wikipedia.org/wiki/PTEN_(gene)>, <https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:9588>, <https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000171862>, <https://www.uniprot.org/uniprotkb/P60484/entry>, <https://www.ncbi.nlm.nih.gov/gene/5728> ;
  schema:citation <https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:9588>, <https://www.uniprot.org/uniprotkb/P60484/entry> ;
  onco:tag "biomarker-parent", "tumor-suppressor" ;
  onco:targetClass "tumor-suppressor" ;
  onco:related <https://onco.cc/biomarkers/pten-alteration/> ;
  onco:cancers <https://onco.cc/cancers/prostate-mhspc/>, <https://onco.cc/cancers/breast-hr-positive/>, <https://onco.cc/cancers/endometrial/>, <https://onco.cc/cancers/glioblastoma/> ;
  onco:drugs <https://onco.cc/drugs/capivasertib/> ;
  onco:terms <https://onco.cc/terms/pten-loss/> .