# OnCo record pvrig (target). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)". Whole corpus: https://onco.cc/api/v1/onco.nt
@prefix schema: <https://schema.org/> .
@prefix onco: <https://onco.cc/ns#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .

<https://onco.cc/targets/pvrig/>
  a schema:BioChemEntity ;
  onco:kind "target" ;
  schema:identifier "pvrig" ;
  schema:name "PVRIG (CD112R)"@en ;
  schema:alternateName "CD112R"@en, "PVR related immunoglobulin domain containing"@en, "C7orf15"@en, "PVRIG" ;
  schema:description "PVRIG is a brake on killer T cells and NK cells that reads CD112 on tumour cells, a cousin of the TIGIT pair. The antibody COM701 blocks it and is being tested in ovarian cancer."@en ;
  schema:url <https://onco.cc/targets/pvrig/> ;
  schema:dateModified "2026-09-24"^^xsd:date ;
  schema:citation <https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:32190>, <https://www.uniprot.org/uniprotkb/Q6DKI7/entry>, <https://www.ncbi.nlm.nih.gov/gene/79037>, <https://clinicaltrials.gov/study/NCT06888921> ;
  onco:tag "checkpoint-map" ;
  onco:targetClass "checkpoint" ;
  schema:sameAs <https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:32190>, <https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000213413>, <https://www.uniprot.org/uniprotkb/Q6DKI7/entry>, <https://www.ncbi.nlm.nih.gov/gene/79037> ;
  onco:related <https://onco.cc/targets/nectin2/>, <https://onco.cc/targets/tigit/>, <https://onco.cc/drugs/nivolumab/> ;
  onco:cancers <https://onco.cc/cancers/ovarian/> ;
  onco:technologies <https://onco.cc/technologies/checkpoint-inhibitor/>, <https://onco.cc/technologies/tigit-blockade/> ;
  onco:pathways <https://onco.cc/pathways/cancer-immunity-cycle/> .