# OnCo record rara (target). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)". Whole corpus: https://onco.cc/api/v1/onco.nt
@prefix schema: <https://schema.org/> .
@prefix onco: <https://onco.cc/ns#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .

<https://onco.cc/targets/rara/>
  a schema:BioChemEntity ;
  onco:kind "target" ;
  schema:identifier "rara" ;
  schema:name "Retinoic acid receptor alpha (RARA)"@en ;
  schema:description "The retinoic acid receptor that, fused to PML in acute promyelocytic leukaemia, blocks white blood cells from maturing. All-trans retinoic acid releases the block and arsenic trioxide destroys the fusion protein, turning a once rapidly fatal leukaemia into one of the most curable."@en ;
  schema:url <https://onco.cc/targets/rara/> ;
  schema:dateModified "2026-09-04"^^xsd:date ;
  schema:sameAs <https://en.wikipedia.org/wiki/Retinoic_acid_receptor_alpha>, <https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:9864>, <https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000131759>, <https://www.uniprot.org/uniprotkb/P10276/entry>, <https://www.ncbi.nlm.nih.gov/gene/5914> ;
  schema:citation <https://www.uniprot.org/uniprotkb/P10276/entry> ;
  schema:alternateName "RARA" ;
  onco:targetClass "nuclear-receptor" ;
  onco:firstDescribed "1987"^^xsd:gYear ;
  onco:cancers <https://onco.cc/cancers/aml/> ;
  onco:drugs <https://onco.cc/drugs/tretinoin-atra/>, <https://onco.cc/drugs/arsenic-trioxide/> .