# OnCo record ras-mapk (pathway). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)". Whole corpus: https://onco.cc/api/v1/onco.nt
@prefix schema: <https://schema.org/> .
@prefix onco: <https://onco.cc/ns#> .
@prefix owl: <http://www.w3.org/2002/07/owl#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .

<https://onco.cc/pathways/ras-mapk/>
  a schema:BioChemEntity ;
  onco:kind "pathway" ;
  schema:identifier "ras-mapk" ;
  schema:name "RAS / RAF / MEK / ERK (MAPK)"@en ;
  schema:description "The RAS-MAPK pathway is the cell's 'divide' relay. A signal at the surface flips RAS on, which passes to RAF, MEK, and ERK, which tell the nucleus to make the cell divide. KRAS and BRAF mutations jam it in the on position."@en ;
  schema:url <https://onco.cc/pathways/ras-mapk/> ;
  schema:dateModified "2026-09-04"^^xsd:date ;
  schema:sameAs <https://en.wikipedia.org/wiki/MAPK/ERK_pathway> ;
  owl:sameAs <http://www.wikidata.org/entity/Q14197552> ;
  schema:citation <https://en.wikipedia.org/wiki/MAPK/ERK_pathway> ;
  onco:cancers <https://onco.cc/cancers/pancreatic/>, <https://onco.cc/cancers/colorectal/>, <https://onco.cc/cancers/nsclc/>, <https://onco.cc/cancers/melanoma/>, <https://onco.cc/cancers/gallbladder/> ;
  onco:targets <https://onco.cc/targets/kras/>, <https://onco.cc/targets/braf/>, <https://onco.cc/targets/egfr/>, <https://onco.cc/targets/alk/>, <https://onco.cc/targets/ret/>, <https://onco.cc/targets/met/>, <https://onco.cc/targets/ntrk/>, <https://onco.cc/targets/fgfr2/>, <https://onco.cc/targets/kit/>, <https://onco.cc/targets/nras/>, <https://onco.cc/targets/shp2/>, <https://onco.cc/targets/nf1/> ;
  onco:drugs <https://onco.cc/drugs/sotorasib/>, <https://onco.cc/drugs/adagrasib/>, <https://onco.cc/drugs/daraxonrasib/>, <https://onco.cc/drugs/encorafenib/>, <https://onco.cc/drugs/osimertinib/>, <https://onco.cc/drugs/lorlatinib/> .