# OnCo record receptor-conversion-breast (term). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)". Whole corpus: https://onco.cc/api/v1/onco.nt
@prefix schema: <https://schema.org/> .
@prefix onco: <https://onco.cc/ns#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .

<https://onco.cc/terms/receptor-conversion-breast/>
  a schema:DefinedTerm ;
  onco:kind "term" ;
  schema:identifier "receptor-conversion-breast" ;
  schema:name "Receptor conversion: when the receptors change between the primary and a recurrence"@en ;
  schema:alternateName "receptor conversion"@en, "receptor discordance"@en, "receptor status change"@en, "ER conversion"@en, "HER2 conversion"@en, "retesting at recurrence"@en, "rebiopsy at relapse"@en, "biopsy of metastasis"@en, "discordance primary metastasis"@en ;
  schema:description "The receptors measured on the original tumour are not always the receptors of a cancer that comes back years later. On meta-analysis about a fifth of oestrogen receptor-positive primaries had become negative in their metastases, and about half had lost the progesterone receptor. It is why a returning cancer is biopsied again rather than treated from the old report."@en ;
  schema:url <https://onco.cc/terms/receptor-conversion-breast/> ;
  schema:dateModified "2026-09-25"^^xsd:date ;
  schema:citation <https://doi.org/10.1093/jnci/djx273>, <https://www.nice.org.uk/guidance/cg81/chapter/Diagnosis-and-assessment>, <https://www.rcpath.org/resourceLibrary/g148-dataset-for-histopathological-reporting-of-breast-disease-in-surgical-excision-specimens-of-breast-cancer.html> ;
  onco:related <https://onco.cc/terms/her2-low/>, <https://onco.cc/terms/endocrine-resistance/>, <https://onco.cc/terms/core-needle-biopsy/>, <https://onco.cc/terms/esr1-mutation/> ;
  onco:cancers <https://onco.cc/cancers/breast-cancer/>, <https://onco.cc/cancers/breast-hr-positive/>, <https://onco.cc/cancers/breast-her2-positive/>, <https://onco.cc/cancers/tnbc/>, <https://onco.cc/cancers/her2-low-metastatic-breast-cancer/>, <https://onco.cc/cancers/hr-positive-metastatic-post-cdk46/> ;
  onco:sections <https://onco.cc/fronts/diagnostics/> ;
  onco:terms <https://onco.cc/terms/er-pr-scoring-breast/>, <https://onco.cc/terms/her2-testing-uk-breast/>, <https://onco.cc/terms/er-pr-negative-threshold/>, <https://onco.cc/terms/her2-low/>, <https://onco.cc/terms/endocrine-resistance/>, <https://onco.cc/terms/esr1-mutation/> .