# OnCo record rechallenge (term). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)". Whole corpus: https://onco.cc/api/v1/onco.nt
@prefix schema: <https://schema.org/> .
@prefix onco: <https://onco.cc/ns#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .

<https://onco.cc/terms/rechallenge/>
  a schema:DefinedTerm ;
  onco:kind "term" ;
  schema:identifier "rechallenge" ;
  schema:name "Rechallenge and retreatment"@en ;
  schema:alternateName "re-challenge"@en, "rechallenged"@en, "retreatment"@en, "re-treatment"@en, "re-treated"@en, "platinum rechallenge"@en, "anti-EGFR rechallenge"@en, "immunotherapy rechallenge"@en, "re-exposure"@en, "re-induction"@en, "drug holiday"@en, "treatment holiday"@en, "treatment break"@en, "intermittent therapy"@en, "intermittent dosing"@en, "stop-and-restart"@en, "stop and go"@en, "drug holidays"@en ;
  schema:description "Giving a drug again after a break, on the theory that the cancer's resistance faded while it was off the drug. Sometimes it works: bowel cancers can respond again to EGFR antibodies once resistant clones have receded."@en ;
  schema:url <https://onco.cc/terms/rechallenge/> ;
  schema:dateModified "2026-09-09"^^xsd:date ;
  schema:sameAs <https://en.wikipedia.org/wiki/Drug_holiday> ;
  schema:citation <https://en.wikipedia.org/wiki/Drug_holiday> ;
  onco:related <https://onco.cc/terms/platinum-sensitivity/>, <https://onco.cc/terms/fixed-duration/>, <https://onco.cc/pathways/clonal-evolution/>, <https://onco.cc/terms/cross-resistance/> ;
  onco:sections <https://onco.cc/fronts/chemotherapy/> .