# OnCo record redifferentiation-rai (pairing). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)". Whole corpus: https://onco.cc/api/v1/onco.nt
@prefix schema: <https://schema.org/> .
@prefix onco: <https://onco.cc/ns#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .

<https://onco.cc/pairings/redifferentiation-rai/>
  a schema:MedicalTherapy ;
  onco:kind "pairing" ;
  schema:identifier "redifferentiation-rai" ;
  schema:name "MAPK inhibitor redifferentiation → radioiodine"@en ;
  schema:description "A short course of a MEK or BRAF pill can coax iodine-resistant thyroid cancer into taking up iodine again, letting radioactive iodine work once more."@en ;
  schema:url <https://onco.cc/pairings/redifferentiation-rai/> ;
  schema:dateModified "2026-09-07"^^xsd:date ;
  schema:citation <https://clinicaltrials.gov/study/NCT01843062> ;
  onco:cancers <https://onco.cc/cancers/thyroid/> ;
  onco:technologies <https://onco.cc/technologies/kinase-inhibitors/>, <https://onco.cc/technologies/radioiodine-therapy/> ;
  onco:drugs <https://onco.cc/drugs/radioactive-iodine/>, <https://onco.cc/drugs/dabrafenib-trametinib/> ;
  onco:pathways <https://onco.cc/pathways/ras-mapk/> ;
  onco:terms <https://onco.cc/terms/rai-refractory/> ;
  onco:trials <https://onco.cc/trials/astra/> ;
  onco:pairs <https://onco.cc/technologies/kinase-inhibitors/>, <https://onco.cc/technologies/radioiodine-therapy/> .