# OnCo record refractory (term). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)". Whole corpus: https://onco.cc/api/v1/onco.nt
@prefix schema: <https://schema.org/> .
@prefix onco: <https://onco.cc/ns#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .

<https://onco.cc/terms/refractory/>
  a schema:DefinedTerm ;
  onco:kind "term" ;
  schema:identifier "refractory" ;
  schema:name "Refractory"@en ;
  schema:alternateName "treatment-refractory"@en, "chemo-refractory"@en, "chemorefractory"@en, "platinum-refractory"@en, "primary refractory"@en, "refractory disease"@en, "refractory to"@en, "did not respond"@en, "failed to respond"@en, "unresponsive"@en, "treatment-resistant"@en, "heavily pretreated"@en, "heavily pre-treated"@en, "pretreated"@en, "pre-treated"@en ;
  schema:description "Cancer that does not respond to a treatment at all, or grows straight through it. Distinct from relapse, where the cancer responded first and came back later."@en ;
  schema:url <https://onco.cc/terms/refractory/> ;
  schema:dateModified "2026-09-09"^^xsd:date ;
  schema:sameAs <https://en.wikipedia.org/wiki/Resistant_cancer> ;
  schema:citation <https://www.cancer.gov/publications/dictionaries/cancer-terms/def/refractory-cancer> ;
  onco:related <https://onco.cc/terms/resistance/>, <https://onco.cc/terms/relapse-recurrence/>, <https://onco.cc/terms/progression/>, <https://onco.cc/terms/first-line/>, <https://onco.cc/terms/accelerated-approval/> .