# OnCo record rejuv-frontier-immune-reconstitution (technology). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)". Whole corpus: https://onco.cc/api/v1/onco.nt
@prefix schema: <https://schema.org/> .
@prefix onco: <https://onco.cc/ns#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .

<https://onco.cc/technologies/rejuv-frontier-immune-reconstitution/>
  a schema:MedicalTherapy ;
  onco:kind "technology" ;
  schema:identifier "rejuv-frontier-immune-reconstitution" ;
  schema:name "Rebuilding the immune system after treatment"@en ;
  schema:description "Chemotherapy, a transplant and CAR-T empty out the immune system, and rebuilding it takes months to years. Blood counts come back before protection does: the antibodies built up over a lifetime, from childhood jabs and from infections, are largely lost after a transplant. Re-vaccination puts them back, on a published schedule."@en ;
  schema:url <https://onco.cc/technologies/rejuv-frontier-immune-reconstitution/> ;
  schema:dateModified "2026-10-02"^^xsd:date ;
  schema:sameAs <https://en.wikipedia.org/wiki/Immunosenescence> ;
  schema:citation <https://doi.org/10.1016/S1473-3099(18)30600-5>, <https://doi.org/10.1093/cid/cit684>, <https://www.gov.uk/government/publications/immunisation-of-individuals-with-underlying-medical-conditions-the-green-book-chapter-7>, <https://doi.org/10.1182/blood-2017-07-793760>, <https://doi.org/10.1038/25374> ;
  onco:status "standard-of-care" ;
  onco:tag "rejuvenation", "survivorship", "evidence:strong", "infection", "vaccination" ;
  onco:sections <https://onco.cc/fronts/rejuvenation/>, <https://onco.cc/fronts/supportive-care/> ;
  onco:technologies <https://onco.cc/technologies/allogeneic-hsct/>, <https://onco.cc/technologies/autologous-stem-cell-transplant/>, <https://onco.cc/technologies/car-t/>, <https://onco.cc/technologies/survivorship-care-plan/> ;
  onco:drugs <https://onco.cc/drugs/rituximab/> ;
  onco:terms <https://onco.cc/terms/late-effects/> ;
  onco:bottlenecks <https://onco.cc/bottlenecks/b-survivorship/>, <https://onco.cc/bottlenecks/b-toxicity-qol/> .