# OnCo record rejuv-paed-pituitary-and-puberty (technology). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)". Whole corpus: https://onco.cc/api/v1/onco.nt
@prefix schema: <https://schema.org/> .
@prefix onco: <https://onco.cc/ns#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .

<https://onco.cc/technologies/rejuv-paed-pituitary-and-puberty/>
  a schema:MedicalTherapy ;
  onco:kind "technology" ;
  schema:identifier "rejuv-paed-pituitary-and-puberty" ;
  schema:name "The pituitary, puberty and the hypothalamic axis after cranial radiotherapy in childhood"@en ;
  schema:description "Radiotherapy near the base of the brain damages the gland that runs growth, puberty, the thyroid and the stress response, in that order of sensitivity. In 748 survivors treated with cranial radiotherapy, 46.5 per cent had growth hormone deficiency, 10.8 per cent sex hormone deficiency, 7.5 per cent thyroid deficiency and 4 per cent adrenal deficiency, and most of it had not been treated."@en ;
  schema:url <https://onco.cc/technologies/rejuv-paed-pituitary-and-puberty/> ;
  schema:dateModified "2026-10-02"^^xsd:date ;
  schema:sameAs <https://en.wikipedia.org/wiki/Hypopituitarism> ;
  schema:citation <https://doi.org/10.1200/JCO.2014.56.7933>, <https://doi.org/10.1111/cen.12964>, <https://doi.org/10.1001/jama.2013.6296>, <https://www.ighg.org/guidelines/>, <https://childrensoncologygroup.org/survivorship/> ;
  onco:status "standard-of-care" ;
  onco:tag "rejuvenation", "survivorship", "paediatric", "late-effects", "evidence:strong" ;
  onco:related <https://onco.cc/collections/sjlife/>, <https://onco.cc/collections/ighg/>, <https://onco.cc/technologies/menopause-after-cancer-treatment/> ;
  onco:cancers <https://onco.cc/cancers/childhood-cancers/>, <https://onco.cc/cancers/medulloblastoma/>, <https://onco.cc/cancers/paediatric-low-grade-glioma/>, <https://onco.cc/cancers/paediatric-high-grade-glioma/>, <https://onco.cc/cancers/all-leukemia/>, <https://onco.cc/cancers/nasopharyngeal/> ;
  onco:sections <https://onco.cc/fronts/rejuvenation/>, <https://onco.cc/fronts/supportive-care/>, <https://onco.cc/fronts/hormonal/> ;
  onco:technologies <https://onco.cc/technologies/rejuv-paed-growth-and-height/>, <https://onco.cc/technologies/rejuv-paed-fertility-female/>, <https://onco.cc/technologies/rejuv-paed-fertility-male/>, <https://onco.cc/technologies/rejuv-paed-bone/>, <https://onco.cc/technologies/rejuv-paed-cog-ltfu-guidelines/>, <https://onco.cc/technologies/proton-therapy/>, <https://onco.cc/terms/radiotherapy/> ;
  onco:terms <https://onco.cc/terms/late-effects/> ;
  onco:bottlenecks <https://onco.cc/bottlenecks/b-survivorship/> .