# OnCo record rejuv-trial-proffi (trial). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)". Whole corpus: https://onco.cc/api/v1/onco.nt
@prefix schema: <https://schema.org/> .
@prefix onco: <https://onco.cc/ns#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .

<https://onco.cc/trials/rejuv-trial-proffi/>
  a schema:MedicalTrial ;
  onco:kind "trial" ;
  schema:identifier "rejuv-trial-proffi", "NCT06113016" ;
  schema:name "PROFFi: fisetin and exercise to prevent frailty in breast cancer survivors"@en ;
  schema:alternateName "PROFFi"@en, "NCT06113016"@en ;
  schema:description "The first randomised trial to test a senolytic in people who have had cancer. Four arms crossing fisetin against placebo with tailored supervised exercise against a physical activity handout, and the primary endpoint is how far someone can walk in six minutes."@en ;
  schema:url <https://onco.cc/trials/rejuv-trial-proffi/> ;
  schema:dateModified "2026-10-02"^^xsd:date ;
  schema:citation <https://clinicaltrials.gov/study/NCT06113016> ;
  onco:status "recruiting" ;
  onco:tag "rejuvenation", "survivorship", "open-problem", "biological-ageing", "senolytics", "exercise" ;
  onco:phase "2" ;
  schema:startDate "2024-07-23" ;
  onco:related <https://onco.cc/technologies/rejuv-frontier-senolytics/>, <https://onco.cc/technologies/rejuv-age-senescent-cells-after-treatment/>, <https://onco.cc/technologies/rejuv-age-frailty-and-late-effects/>, <https://onco.cc/bottlenecks/rejuv-agenda-biological-age-as-an-untested-target/>, <https://onco.cc/ideas/idea-rejuv-biological-age-as-a-randomised-endpoint/>, <https://onco.cc/technologies/exercise-prescription-after-cancer/>, <https://onco.cc/roadmaps/rejuvenation-roadmap/> ;
  onco:cancers <https://onco.cc/cancers/breast-cancer/> ;
  onco:sections <https://onco.cc/fronts/rejuvenation/>, <https://onco.cc/fronts/supportive-care/> .