# OnCo record rejuv-tx-b-cell-aplasia-and-immunoglobulin (technology). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)". Whole corpus: https://onco.cc/api/v1/onco.nt
@prefix schema: <https://schema.org/> .
@prefix onco: <https://onco.cc/ns#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .

<https://onco.cc/technologies/rejuv-tx-b-cell-aplasia-and-immunoglobulin/>
  a schema:MedicalTherapy ;
  onco:kind "technology" ;
  schema:identifier "rejuv-tx-b-cell-aplasia-and-immunoglobulin" ;
  schema:name "B-cell aplasia and low antibodies after CAR-T and bispecifics, and immunoglobulin replacement"@en ;
  schema:alternateName "B-cell aplasia"@en, "hypogammaglobulinaemia after CAR-T"@en, "IVIg after CAR-T"@en, "immunoglobulin replacement after bispecifics"@en ;
  schema:description "Treatments aimed at a protein on B cells cannot tell a cancerous B cell from a healthy one, so they remove both, antibody levels fall and infections become more frequent. The fix is to give the antibodies back every few weeks. In one myeloma study, serious infections were ten times less frequent while people were receiving immunoglobulin."@en ;
  schema:url <https://onco.cc/technologies/rejuv-tx-b-cell-aplasia-and-immunoglobulin/> ;
  schema:dateModified "2026-10-02"^^xsd:date ;
  schema:sameAs <https://en.wikipedia.org/wiki/Hypogammaglobulinemia> ;
  schema:citation <https://doi.org/10.1158/2643-3230.BCD-23-0049>, <https://doi.org/10.1182/blood-2017-07-793760>, <https://www.cdc.gov/vaccines/hcp/imz-best-practices/altered-immunocompetence.html>, <https://doi.org/10.1016/j.leukres.2026.108327> ;
  onco:status "standard-of-care" ;
  onco:tag "rejuvenation", "survivorship", "transplant", "evidence:moderate", "immune", "antibody" ;
  onco:related <https://onco.cc/technologies/rejuv-tx-immune-reconstitution-timeline/>, <https://onco.cc/technologies/rejuv-tx-infection-by-phase/>, <https://onco.cc/technologies/rejuv-tx-revaccination/>, <https://onco.cc/technologies/rejuv-tx-prolonged-cytopenias/>, <https://onco.cc/terms/lymphoma-tx-immunoglobulin-replacement/> ;
  onco:sections <https://onco.cc/fronts/rejuvenation/>, <https://onco.cc/fronts/supportive-care/> ;
  onco:technologies <https://onco.cc/technologies/car-t/> ;
  onco:drugs <https://onco.cc/drugs/human-normal-immunoglobulin/>, <https://onco.cc/drugs/rituximab/> ;
  onco:terms <https://onco.cc/terms/hypogammaglobulinaemia/>, <https://onco.cc/terms/late-effects/> ;
  onco:bottlenecks <https://onco.cc/bottlenecks/b-survivorship/>, <https://onco.cc/bottlenecks/b-toxicity-qol/> .