# OnCo record rejuv-tx-icans-and-neurocognition (technology). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)". Whole corpus: https://onco.cc/api/v1/onco.nt
@prefix schema: <https://schema.org/> .
@prefix onco: <https://onco.cc/ns#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .

<https://onco.cc/technologies/rejuv-tx-icans-and-neurocognition/>
  a schema:MedicalTherapy ;
  onco:kind "technology" ;
  schema:identifier "rejuv-tx-icans-and-neurocognition" ;
  schema:name "ICANS, and whether thinking recovers after CAR-T"@en ;
  schema:alternateName "neurotoxicity after CAR-T"@en, "immune effector cell-associated neurotoxicity syndrome"@en, "cognitive recovery after CAR-T"@en, "late neurocognitive effects of CAR-T"@en ;
  schema:description "CAR-T can cause a short-lived brain disturbance in the first weeks: confusion, trouble finding words, tremor, sometimes seizures. It almost always resolves. Afterwards, measured outcomes for most people are close to the general population, while a substantial minority report trouble with memory or concentration."@en ;
  schema:url <https://onco.cc/technologies/rejuv-tx-icans-and-neurocognition/> ;
  schema:dateModified "2026-10-02"^^xsd:date ;
  schema:sameAs <https://en.wikipedia.org/wiki/Cytokine_release_syndrome> ;
  schema:citation <https://doi.org/10.1016/j.bbmt.2019.09.037>, <https://doi.org/10.1002/hsr2.71571>, <https://doi.org/10.3389/fimmu.2026.1749587>, <https://doi.org/10.1182/blood.2023020578> ;
  onco:status "established" ;
  onco:tag "rejuvenation", "survivorship", "transplant", "cell-therapy", "cognition" ;
  onco:related <https://onco.cc/technologies/rejuv-tx-prolonged-cytopenias/>, <https://onco.cc/technologies/rejuv-tx-quality-of-life/>, <https://onco.cc/technologies/cognitive-impairment-after-cancer-treatment/>, <https://onco.cc/technologies/rejuv-tx-secondary-t-cell-malignancy/> ;
  onco:sections <https://onco.cc/fronts/rejuvenation/>, <https://onco.cc/fronts/supportive-care/> ;
  onco:technologies <https://onco.cc/technologies/car-t/> ;
  onco:terms <https://onco.cc/terms/icans/>, <https://onco.cc/terms/crs/>, <https://onco.cc/terms/quality-of-life/>, <https://onco.cc/terms/late-effects/> ;
  onco:bottlenecks <https://onco.cc/bottlenecks/b-toxicity-qol/>, <https://onco.cc/bottlenecks/b-survivorship/> .