# OnCo record retinoblastoma (cancer). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)". Whole corpus: https://onco.cc/api/v1/onco.nt
@prefix schema: <https://schema.org/> .
@prefix onco: <https://onco.cc/ns#> .
@prefix owl: <http://www.w3.org/2002/07/owl#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .

<https://onco.cc/cancers/retinoblastoma/>
  a schema:MedicalCondition ;
  onco:kind "cancer" ;
  schema:identifier "retinoblastoma" ;
  schema:name "Retinoblastoma"@en ;
  schema:description "An eye cancer of infants caused by loss of the RB1 gene, the first tumour-suppressor gene ever found. In rich countries almost every child survives and most eyes are saved by chemotherapy delivered through the eye's artery; in low-income countries, where most cases occur, survival depends on finding it early, and that is the global gap."@en ;
  schema:url <https://onco.cc/cancers/retinoblastoma/> ;
  schema:dateModified "2026-09-08"^^xsd:date ;
  schema:sameAs <https://en.wikipedia.org/wiki/Retinoblastoma> ;
  owl:sameAs <http://www.wikidata.org/entity/Q500695> ;
  schema:citation <https://www.cancer.gov/types/retinoblastoma/patient/retinoblastoma-treatment-pdq>, <https://doi.org/10.1001/jamaoncol.2019.6716>, <https://wechope.org/> ;
  onco:tag "gap-fill", "paediatric", "eye", "hereditary" ;
  onco:related <https://onco.cc/cancers/neuroblastoma/>, <https://onco.cc/cancers/wilms-tumor/>, <https://onco.cc/cancers/hepatoblastoma/>, <https://onco.cc/cancers/rare-childhood-cancers/> ;
  onco:technologies <https://onco.cc/technologies/cytotoxic-chemotherapy/>, <https://onco.cc/technologies/brachytherapy/>, <https://onco.cc/technologies/germline-testing/>, <https://onco.cc/technologies/liquid-biopsy/>, <https://onco.cc/technologies/autologous-stem-cell-transplant/>, <https://onco.cc/technologies/mri/> ;
  onco:targets <https://onco.cc/targets/tp53/> ;
  onco:drugs <https://onco.cc/drugs/melphalan/>, <https://onco.cc/drugs/carboplatin/>, <https://onco.cc/drugs/etoposide/>, <https://onco.cc/drugs/vincristine/>, <https://onco.cc/drugs/topotecan/>, <https://onco.cc/drugs/cyclophosphamide/> ;
  onco:companies <https://onco.cc/companies/childrens-oncology-group/> ;
  onco:institutions <https://onco.cc/institutions/mskcc/> ;
  onco:pathways <https://onco.cc/pathways/p53-cell-cycle/> ;
  onco:terms <https://onco.cc/terms/germline-vs-somatic/> ;
  onco:keyPapers <https://onco.cc/key-papers/paper-global-retinoblastoma-study-jama-oncol/> ;
  onco:pipeline <https://onco.cc/drugs/melphalan/>, <https://onco.cc/technologies/liquid-biopsy/> ;
  onco:standardOfCare <https://onco.cc/drugs/vincristine/>, <https://onco.cc/drugs/etoposide/>, <https://onco.cc/drugs/carboplatin/>, <https://onco.cc/drugs/melphalan/>, <https://onco.cc/drugs/carboplatin/>, <https://onco.cc/drugs/etoposide/>, <https://onco.cc/drugs/vincristine/>, <https://onco.cc/drugs/topotecan/>, <https://onco.cc/technologies/brachytherapy/>, <https://onco.cc/drugs/cyclophosphamide/>, <https://onco.cc/drugs/carboplatin/>, <https://onco.cc/drugs/etoposide/>, <https://onco.cc/technologies/autologous-stem-cell-transplant/>, <https://onco.cc/technologies/imrt-igrt/>, <https://onco.cc/technologies/germline-testing/> .