# OnCo record ripretinib (drug). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)". Whole corpus: https://onco.cc/api/v1/onco.nt
@prefix schema: <https://schema.org/> .
@prefix onco: <https://onco.cc/ns#> .
@prefix owl: <http://www.w3.org/2002/07/owl#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .

<https://onco.cc/drugs/ripretinib/>
  a schema:Drug ;
  onco:kind "drug" ;
  schema:identifier "ripretinib" ;
  schema:name "Ripretinib"@en ;
  schema:description "A fourth-line GIST drug that locks KIT in an off state regardless of which resistance mutation the tumour has acquired."@en ;
  schema:url <https://onco.cc/drugs/ripretinib/> ;
  schema:dateModified "2026-09-07"^^xsd:date ;
  schema:sameAs <https://en.wikipedia.org/wiki/Ripretinib> ;
  owl:sameAs <http://www.wikidata.org/entity/Q27076996> ;
  schema:citation <https://dailymed.nlm.nih.gov/dailymed/search.cfm?query=Ripretinib> ;
  onco:status "approved" ;
  onco:modality "Small-molecule kinase inhibitor (KIT/PDGFRA switch-control)" ;
  schema:alternateName "Qinlock" ;
  onco:approval "US 2020: Advanced GIST after ≥3 prior kinase inhibitors including imatinib" ;
  onco:cancers <https://onco.cc/cancers/sarcoma/>, <https://onco.cc/cancers/gist-imatinib-resistant/> ;
  onco:technologies <https://onco.cc/technologies/kinase-inhibitors/> ;
  onco:targets <https://onco.cc/targets/kit/> ;
  onco:companies <https://onco.cc/companies/deciphera/> ;
  onco:trials <https://onco.cc/trials/invictus/>, <https://onco.cc/trials/insight-gist/>, <https://onco.cc/trials/nct03673501/> .