# OnCo record risk-reducing-surgery-brca-carriers (term). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)". Whole corpus: https://onco.cc/api/v1/onco.nt
@prefix schema: <https://schema.org/> .
@prefix onco: <https://onco.cc/ns#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .

<https://onco.cc/terms/risk-reducing-surgery-brca-carriers/>
  a schema:DefinedTerm ;
  onco:kind "term" ;
  schema:identifier "risk-reducing-surgery-brca-carriers" ;
  schema:name "Risk-reducing surgery for BRCA carriers (bilateral and contralateral mastectomy, salpingo-oophorectomy)"@en ;
  schema:alternateName "Bilateral risk-reducing mastectomy"@en, "Prophylactic mastectomy"@en, "Contralateral risk-reducing mastectomy"@en, "Risk-reducing salpingo-oophorectomy and breast cancer"@en, "Preventive mastectomy"@en ;
  schema:description "Women who carry a BRCA1 or BRCA2 fault can choose to have both breasts removed before any cancer appears, which cuts breast cancer risk by about nine tenths, or to remove the other breast after a first cancer. Removing the ovaries protects against ovarian cancer but, in the largest prospective study, did not lower breast cancer risk in BRCA1 carriers."@en ;
  schema:url <https://onco.cc/terms/risk-reducing-surgery-brca-carriers/> ;
  schema:dateModified "2026-09-24"^^xsd:date ;
  schema:sameAs <https://en.wikipedia.org/wiki/Prophylactic_mastectomy> ;
  schema:citation <https://doi.org/10.1200/jco.2004.04.188>, <https://doi.org/10.1158/1078-0432.ccr-15-1465>, <https://doi.org/10.1093/jnci/djw177>, <https://www.nice.org.uk/guidance/cg164/chapter/Recommendations>, <https://www.cancerresearchuk.org/about-cancer/breast-cancer/risks-causes/family-history-and-inherited-genes>, <https://doi.org/10.1016/s1470-2045(17)30891-4> ;
  onco:tag "breast", "tnbc" ;
  onco:cancers <https://onco.cc/cancers/tnbc/>, <https://onco.cc/cancers/brca-associated-tnbc/>, <https://onco.cc/cancers/breast-cancer/>, <https://onco.cc/cancers/ovarian/> ;
  onco:technologies <https://onco.cc/technologies/germline-testing/> ;
  onco:terms <https://onco.cc/terms/mastectomy/>, <https://onco.cc/terms/germline-brca-testing-criteria-tnbc/>, <https://onco.cc/terms/chemoprevention-and-er-negative-breast-cancer/> .