# OnCo record roman (trial). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)". Whole corpus: https://onco.cc/api/v1/onco.nt
@prefix schema: <https://schema.org/> .
@prefix onco: <https://onco.cc/ns#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .

<https://onco.cc/trials/roman/>
  a schema:MedicalTrial ;
  onco:kind "trial" ;
  schema:identifier "roman", "NCT03689712" ;
  schema:name "ROMAN"@en ;
  schema:alternateName "GTI-4419-301"@en, "Reduction in Oral Mucositis With Avasopasem Manganese"@en ;
  schema:description "ROMAN showed that an infusion of avasopasem before each dose of radiotherapy cut severe mouth ulcers during head and neck chemoradiation from about two thirds of patients to about half and shortened them from 18 days to 8, but the effect was smaller than an earlier trial had promised and the FDA asked for another study before approval."@en ;
  schema:url <https://onco.cc/trials/roman/> ;
  schema:dateModified "2026-09-24"^^xsd:date ;
  schema:citation <https://clinicaltrials.gov/study/NCT03689712>, <https://doi.org/10.1016/j.eclinm.2025.103539> ;
  onco:status "mixed" ;
  onco:phase "3" ;
  onco:cancers <https://onco.cc/cancers/head-and-neck/> ;
  onco:technologies <https://onco.cc/technologies/radioprotectors/> ;
  onco:drugs <https://onco.cc/drugs/avasopasem-manganese/>, <https://onco.cc/drugs/cisplatin/> ;
  onco:companies <https://onco.cc/companies/galera-therapeutics/> ;
  onco:keyPapers <https://onco.cc/key-papers/paper-roman-anderson-eclinicalmedicine-2025/> .