# OnCo record romana-1-2 (trial). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)". Whole corpus: https://onco.cc/api/v1/onco.nt
@prefix schema: <https://schema.org/> .
@prefix onco: <https://onco.cc/ns#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .

<https://onco.cc/trials/romana-1-2/>
  a schema:MedicalTrial ;
  onco:kind "trial" ;
  schema:identifier "romana-1-2", "NCT01387269" ;
  schema:name "ROMANA 1 and ROMANA 2"@en ;
  schema:description "ROMANA 1 and 2 were two phase 3 trials of an appetite-hormone mimic in lung cancer patients with wasting. Patients gained muscle but not grip strength, which split regulators: approved in Japan, rejected in Europe."@en ;
  schema:url <https://onco.cc/trials/romana-1-2/> ;
  schema:dateModified "2026-09-08"^^xsd:date ;
  schema:citation <https://clinicaltrials.gov/study/NCT01387269>, <https://clinicaltrials.gov/study/NCT01387282>, <https://doi.org/10.1016/S1470-2045(15)00558-6> ;
  onco:status "mixed" ;
  onco:phase "3" ;
  schema:startDate "2011-07" ;
  onco:related <https://onco.cc/ideas/idea-bio2-anamorelin-access/>, <https://onco.cc/ideas/idea-bio2-cachexia-function-endpoint/> ;
  onco:cancers <https://onco.cc/cancers/nsclc/> ;
  onco:sections <https://onco.cc/fronts/nutrition-lifestyle/>, <https://onco.cc/fronts/supportive-care/> ;
  onco:technologies <https://onco.cc/technologies/cachexia-appetite-pharmacotherapy/>, <https://onco.cc/technologies/cachexia-therapy/> ;
  onco:companies <https://onco.cc/companies/helsinn/> ;
  onco:institutions <https://onco.cc/institutions/ncc-japan/> ;
  onco:pathways <https://onco.cc/pathways/cachexia-biology/> ;
  onco:terms <https://onco.cc/terms/cachexia/>, <https://onco.cc/terms/sarcopenia/>, <https://onco.cc/terms/body-composition/> ;
  onco:bottlenecks <https://onco.cc/bottlenecks/b-cachexia-supportive/>, <https://onco.cc/bottlenecks/b-regulatory-fragmentation/> ;
  onco:keyPapers <https://onco.cc/key-papers/paper-romana-1-2-lancet-oncol-2016/> .