# OnCo record rrm1 (target). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)". Whole corpus: https://onco.cc/api/v1/onco.nt
@prefix schema: <https://schema.org/> .
@prefix onco: <https://onco.cc/ns#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .

<https://onco.cc/targets/rrm1/>
  a schema:BioChemEntity ;
  onco:kind "target" ;
  schema:identifier "rrm1" ;
  schema:name "Ribonucleotide reductase (RRM1)"@en ;
  schema:description "The enzyme that makes DNA building blocks from RNA building blocks. Gemcitabine's active form shuts it down and hydroxyurea quenches its catalytic radical, starving dividing cells of the nucleotides they need."@en ;
  schema:url <https://onco.cc/targets/rrm1/> ;
  schema:dateModified "2026-09-04"^^xsd:date ;
  schema:sameAs <https://en.wikipedia.org/wiki/RRM1>, <https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:10451>, <https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000167325>, <https://www.uniprot.org/uniprotkb/P23921/entry>, <https://www.ncbi.nlm.nih.gov/gene/6240> ;
  schema:citation <https://www.uniprot.org/uniprotkb/P23921/entry> ;
  schema:alternateName "RRM1" ;
  onco:targetClass "enzyme" ;
  onco:firstDescribed "1991"^^xsd:gYear ;
  onco:cancers <https://onco.cc/cancers/pancreatic/>, <https://onco.cc/cancers/nsclc/>, <https://onco.cc/cancers/urothelial/> ;
  onco:drugs <https://onco.cc/drugs/gemcitabine/>, <https://onco.cc/drugs/hydroxyurea/> .