# OnCo record rspo-fusion (term). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)". Whole corpus: https://onco.cc/api/v1/onco.nt
@prefix schema: <https://schema.org/> .
@prefix onco: <https://onco.cc/ns#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .

<https://onco.cc/terms/rspo-fusion/>
  a schema:DefinedTerm ;
  onco:kind "term" ;
  schema:identifier "rspo-fusion" ;
  schema:name "R-spondin fusion"@en ;
  schema:alternateName "RSPO fusion"@en, "RSPO2 fusion"@en, "RSPO3 fusion"@en, "PTPRK-RSPO3"@en, "EIF3E-RSPO2"@en, "R-spondin gene fusion"@en ;
  schema:description "R-spondin fusions are rearrangements that make a bowel tumour overproduce a protein which turns the Wnt growth pathway up from outside the cell. They occur in about one colon tumour in ten and almost never alongside the usual APC fault, so they look like an alternative way into the same pathway."@en ;
  schema:url <https://onco.cc/terms/rspo-fusion/> ;
  schema:dateModified "2026-09-24"^^xsd:date ;
  schema:sameAs <https://en.wikipedia.org/wiki/R-spondin_1> ;
  schema:citation <https://doi.org/10.1038/nature11282>, <https://doi.org/10.1038/nm.3967> ;
  onco:tag "gi", "colorectal" ;
  onco:cancers <https://onco.cc/cancers/colorectal/>, <https://onco.cc/cancers/colon-cancer/>, <https://onco.cc/cancers/rectal-cancer/> ;
  onco:technologies <https://onco.cc/technologies/cgp/> ;
  onco:pathways <https://onco.cc/pathways/wnt/> ;
  onco:terms <https://onco.cc/terms/adenoma-carcinoma-sequence/>, <https://onco.cc/terms/cms-subtypes/>, <https://onco.cc/terms/germline-vs-somatic/> .