# OnCo record safety-switch-car-t (technology). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)". Whole corpus: https://onco.cc/api/v1/onco.nt
@prefix schema: <https://schema.org/> .
@prefix onco: <https://onco.cc/ns#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .

<https://onco.cc/technologies/safety-switch-car-t/>
  a schema:MedicalTherapy ;
  onco:kind "technology" ;
  schema:identifier "safety-switch-car-t" ;
  schema:name "Safety-switch (suicide gene) CAR-T"@en ;
  schema:alternateName "suicide gene"@en, "safety switch"@en, "inducible caspase 9"@en, "iCasp9"@en, "iC9"@en, "EGFRt"@en, "truncated EGFR switch"@en, "off switch for CAR-T"@en ;
  schema:description "An extra gene built into engineered immune cells that lets doctors destroy those cells quickly with a drug if they start causing serious harm. It is an off switch for a living medicine."@en ;
  schema:url <https://onco.cc/technologies/safety-switch-car-t/> ;
  schema:dateModified "2026-11-03"^^xsd:date ;
  schema:citation <https://doi.org/10.1056/NEJMoa1106152>, <https://doi.org/10.1182/blood-2011-02-337360> ;
  onco:status "phase-2" ;
  onco:cancers <https://onco.cc/cancers/neuroblastoma/> ;
  onco:sections <https://onco.cc/fronts/cell-therapy/> ;
  onco:technologies <https://onco.cc/technologies/car-t/>, <https://onco.cc/technologies/armored-car/> ;
  onco:drugs <https://onco.cc/drugs/cetuximab/> ;
  onco:companies <https://onco.cc/companies/bellicum/> ;
  onco:terms <https://onco.cc/terms/crs/> ;
  onco:trials <https://onco.cc/trials/gd2-cart01/> .