# OnCo record safir-abc10 (trial). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)". Whole corpus: https://onco.cc/api/v1/onco.nt
@prefix schema: <https://schema.org/> .
@prefix onco: <https://onco.cc/ns#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .

<https://onco.cc/trials/safir-abc10/>
  a schema:MedicalTrial ;
  onco:kind "trial" ;
  schema:identifier "safir-abc10", "NCT05615818" ;
  schema:name "SAFIR-ABC10"@en ;
  schema:description "SAFIR-ABC10 profiles the tumour during first-line chemotherapy and then randomises people with a targetable change to a matched drug (for HER2, FGFR2, IDH1, BRAF or DNA repair defects) or to standard continuation. With 20 NHS hospitals taking part, it is the biggest precision-medicine trial open to UK patients with gallbladder cancer."@en ;
  schema:url <https://onco.cc/trials/safir-abc10/> ;
  schema:dateModified "2026-09-24"^^xsd:date ;
  schema:citation <https://clinicaltrials.gov/study/NCT05615818> ;
  onco:status "recruiting" ;
  onco:phase "3" ;
  onco:cancers <https://onco.cc/cancers/gallbladder/>, <https://onco.cc/cancers/cholangiocarcinoma/>, <https://onco.cc/cancers/intrahepatic-cholangiocarcinoma/>, <https://onco.cc/cancers/extrahepatic-cholangiocarcinoma/>, <https://onco.cc/cancers/biliary-tract-cancer/> ;
  onco:technologies <https://onco.cc/technologies/cgp/>, <https://onco.cc/technologies/kinase-inhibitors/>, <https://onco.cc/technologies/bispecific-antibody/>, <https://onco.cc/technologies/parp-inhibitor/>, <https://onco.cc/technologies/cytotoxic-chemotherapy/> ;
  onco:targets <https://onco.cc/targets/her2/>, <https://onco.cc/targets/fgfr2/>, <https://onco.cc/targets/idh/>, <https://onco.cc/targets/braf/> ;
  onco:drugs <https://onco.cc/drugs/futibatinib/>, <https://onco.cc/drugs/ivosidenib/>, <https://onco.cc/drugs/zanidatamab/>, <https://onco.cc/drugs/trastuzumab/>, <https://onco.cc/drugs/neratinib/>, <https://onco.cc/drugs/niraparib/>, <https://onco.cc/drugs/gemcitabine-cisplatin/> ;
  onco:institutions <https://onco.cc/institutions/uclh/>, <https://onco.cc/institutions/royal-marsden/>, <https://onco.cc/institutions/leeds-cancer-centre/> ;
  onco:terms <https://onco.cc/terms/basket-umbrella-platform/>, <https://onco.cc/terms/master-protocol/> .