# OnCo record sam-e-supplements (technology). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)". Whole corpus: https://onco.cc/api/v1/onco.nt
@prefix schema: <https://schema.org/> .
@prefix onco: <https://onco.cc/ns#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .

<https://onco.cc/technologies/sam-e-supplements/>
  a schema:MedicalTherapy ;
  onco:kind "technology" ;
  schema:identifier "sam-e-supplements" ;
  schema:name "SAM-e (S-adenosylmethionine)"@en ;
  schema:alternateName "SAMe"@en, "S-adenosyl-L-methionine"@en, "Ademetionine"@en ;
  schema:description "SAM-e is sold for mood, joints and the liver. Evidence for depression is mixed, it did not help hot flushes, and small studies of protecting the liver during chemotherapy need confirming. It can trigger mania in bipolar disorder and adds to the serotonin effects of antidepressants."@en ;
  schema:url <https://onco.cc/technologies/sam-e-supplements/> ;
  schema:dateModified "2026-11-04"^^xsd:date ;
  schema:citation <https://www.mskcc.org/cancer-care/integrative-medicine/herbs/sam-e> ;
  onco:status "phase-2" ;
  onco:tag "complementary", "supportive-care", "evidence:insufficient" ;
  onco:related <https://onco.cc/technologies/five-htp-supplements/>, <https://onco.cc/technologies/n-acetylcysteine-supplements/> ;
  onco:sections <https://onco.cc/fronts/supportive-care/> ;
  onco:technologies <https://onco.cc/technologies/integrative-oncology/>, <https://onco.cc/technologies/dietary-supplements-treatment-interactions/>, <https://onco.cc/technologies/psycho-oncology/> ;
  onco:bottlenecks <https://onco.cc/bottlenecks/b-toxicity-qol/> .