# OnCo record second-primary-bladder-after-cyclophosphamide (term). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)". Whole corpus: https://onco.cc/api/v1/onco.nt
@prefix schema: <https://schema.org/> .
@prefix onco: <https://onco.cc/ns#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .

<https://onco.cc/terms/second-primary-bladder-after-cyclophosphamide/>
  a schema:DefinedTerm ;
  onco:kind "term" ;
  schema:identifier "second-primary-bladder-after-cyclophosphamide" ;
  schema:name "Bladder cancer after cyclophosphamide"@en ;
  schema:alternateName "Cyclophosphamide bladder cancer"@en, "Haemorrhagic cystitis and bladder cancer"@en, "Acrolein bladder injury"@en ;
  schema:description "Cyclophosphamide is one of the few cancer drugs that has been shown to cause a specific solid cancer, in the bladder, and the risk depends steeply on the total dose given. Blood in the urine years after treatment with it is a reason to be investigated rather than reassured, and the cumulative dose on your treatment summary is what tells you where you sit."@en ;
  schema:url <https://onco.cc/terms/second-primary-bladder-after-cyclophosphamide/> ;
  schema:dateModified "2026-10-02"^^xsd:date ;
  schema:sameAs <https://en.wikipedia.org/wiki/Cyclophosphamide> ;
  schema:citation <https://doi.org/10.1093/jnci/87.7.524>, <https://doi.org/10.1002/cncr.30164> ;
  onco:tag "rejuvenation", "survivorship", "second-cancers", "bladder", "chemotherapy" ;
  onco:related <https://onco.cc/terms/rejuv-second-alkylating-agents-and-myeloid-neoplasms/>, <https://onco.cc/terms/rejuv-second-cancers-overview/>, <https://onco.cc/terms/rejuv-second-choices-made-at-treatment/> ;
  onco:cancers <https://onco.cc/cancers/urothelial/>, <https://onco.cc/cancers/non-hodgkin-lymphoma/>, <https://onco.cc/cancers/breast-cancer/> ;
  onco:sections <https://onco.cc/fronts/rejuvenation/>, <https://onco.cc/fronts/supportive-care/> ;
  onco:technologies <https://onco.cc/technologies/cytotoxic-chemotherapy/>, <https://onco.cc/technologies/survivorship-care-plan/> ;
  onco:drugs <https://onco.cc/drugs/cyclophosphamide/> ;
  onco:terms <https://onco.cc/terms/secondary-malignancy/>, <https://onco.cc/terms/late-effects/> ;
  onco:bottlenecks <https://onco.cc/bottlenecks/b-toxicity-qol/>, <https://onco.cc/bottlenecks/b-survivorship/>, <https://onco.cc/bottlenecks/b-dose-optimisation/> .