# OnCo record seed-and-soil-hypothesis (term). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)". Whole corpus: https://onco.cc/api/v1/onco.nt
@prefix schema: <https://schema.org/> .
@prefix onco: <https://onco.cc/ns#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .

<https://onco.cc/terms/seed-and-soil-hypothesis/>
  a schema:DefinedTerm ;
  onco:kind "term" ;
  schema:identifier "seed-and-soil-hypothesis" ;
  schema:name "Seed and soil hypothesis of metastasis (Paget)"@en ;
  schema:alternateName "seed and soil"@en, "Paget's hypothesis"@en, "organ tropism"@en, "pre-metastatic niche"@en, "Ewing's mechanical hypothesis"@en ;
  schema:description "Stephen Paget asked in 1889 why breast cancer spread to some organs more than blood flow could explain, and answered that a travelling cancer cell (the seed) grows only where the organ (the soil) suits it. Ignored for most of a century, then confirmed: each cancer has favoured destinations, tumours prepare distant organs before cells arrive, and drugs that change the soil reduce bone metastases."@en ;
  schema:url <https://onco.cc/terms/seed-and-soil-hypothesis/> ;
  schema:dateModified "2026-09-17"^^xsd:date ;
  schema:sameAs <https://en.wikipedia.org/wiki/Metastasis> ;
  schema:citation <https://doi.org/10.1016/S0140-6736(00)49915-0>, <https://doi.org/10.1038/nrc1098>, <https://doi.org/10.1002/ijc.26031>, <https://doi.org/10.1038/nature04186>, <https://doi.org/10.1038/nature03799>, <https://doi.org/10.1016/S0140-6736(15)60908-4> ;
  onco:tag "theory" ;
  onco:related <https://onco.cc/pathways/theories-of-cancer/>, <https://onco.cc/terms/metastasis/>, <https://onco.cc/terms/microenvironment-inflammation-theory/>, <https://onco.cc/terms/clonal-evolution-theory/>, <https://onco.cc/pathways/organ-tropism-seed-soil/>, <https://onco.cc/pathways/pre-metastatic-niche/>, <https://onco.cc/pathways/metastatic-cascade/>, <https://onco.cc/pathways/tumor-dormancy/>, <https://onco.cc/pathways/intravasation-ctc-survival/>, <https://onco.cc/terms/disseminated-tumor-cells/> ;
  onco:cancers <https://onco.cc/cancers/breast-cancer/>, <https://onco.cc/cancers/prostate/>, <https://onco.cc/cancers/uveal-melanoma/>, <https://onco.cc/cancers/colorectal/> ;
  onco:drugs <https://onco.cc/drugs/zoledronic-acid/>, <https://onco.cc/drugs/denosumab/> ;
  onco:pathways <https://onco.cc/pathways/organ-tropism-seed-soil/>, <https://onco.cc/pathways/pre-metastatic-niche/>, <https://onco.cc/pathways/metastatic-cascade/>, <https://onco.cc/pathways/tumor-dormancy/>, <https://onco.cc/pathways/intravasation-ctc-survival/> ;
  onco:keyPapers <https://onco.cc/key-papers/paper-early-breast-cancer-trialists-collaborative-group-ebctcg-lancet/>, <https://onco.cc/key-papers/paper-langley-int-j-cancer/>, <https://onco.cc/key-papers/paper-paget-cancer-metastasis-rev/>, <https://onco.cc/key-papers/paper-minn-nature/>, <https://onco.cc/key-papers/paper-kaplan-nature/>, <https://onco.cc/key-papers/paper-fidler-nat-rev-cancer/> .