# OnCo record senescence (pathway). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)". Whole corpus: https://onco.cc/api/v1/onco.nt
@prefix schema: <https://schema.org/> .
@prefix onco: <https://onco.cc/ns#> .
@prefix owl: <http://www.w3.org/2002/07/owl#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .

<https://onco.cc/pathways/senescence/>
  a schema:BioChemEntity ;
  onco:kind "pathway" ;
  schema:identifier "senescence" ;
  schema:name "Cellular senescence"@en ;
  schema:description "Damaged cells can stop dividing permanently instead of dying. That protects against cancer at first, but senescent cells linger, secrete inflammatory signals, and after chemotherapy can help tumours relapse, so removing them (senolytics) is a new strategy."@en ;
  schema:url <https://onco.cc/pathways/senescence/> ;
  schema:dateModified "2026-09-08"^^xsd:date ;
  schema:sameAs <https://en.wikipedia.org/wiki/Cellular_senescence> ;
  owl:sameAs <http://www.wikidata.org/entity/Q9075999> ;
  schema:citation <https://doi.org/10.1038/s41571-022-00668-4> ;
  onco:tag "mechanism" ;
  onco:technologies <https://onco.cc/technologies/cdk46-inhibitor/> ;
  onco:targets <https://onco.cc/targets/tp53/>, <https://onco.cc/targets/cdk4-6/>, <https://onco.cc/targets/bcl2/> ;
  onco:institutions <https://onco.cc/institutions/mskcc/>, <https://onco.cc/institutions/cold-spring-harbor/>, <https://onco.cc/institutions/mayo-clinic/> ;
  onco:pathways <https://onco.cc/pathways/p53-cell-cycle/>, <https://onco.cc/pathways/apoptosis-bcl2/>, <https://onco.cc/pathways/inflammation-nfkb/>, <https://onco.cc/pathways/tumor-microenvironment/> ;
  onco:terms <https://onco.cc/terms/senescent-cells/> ;
  onco:keyPapers <https://onco.cc/key-papers/paper-schmitt-nat-rev-clin-oncol/> .