# OnCo record setd2 (target). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)". Whole corpus: https://onco.cc/api/v1/onco.nt
@prefix schema: <https://schema.org/> .
@prefix onco: <https://onco.cc/ns#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .

<https://onco.cc/targets/setd2/>
  a schema:BioChemEntity ;
  onco:kind "target" ;
  schema:identifier "setd2" ;
  schema:name "SETD2"@en ;
  schema:alternateName "SET domain containing 2, histone lysine methyltransferase"@en, "Histone-lysine N-methyltransferase SETD2"@en, "HIF-1"@en, "KIAA1732"@en, "FLJ23184"@en, "KMT3A"@en, "SETD2" ;
  schema:description "SETD2 (Histone-lysine N-methyltransferase SETD2) is a protein that switches other genes on and off. The public catalogues list it as a drug target, an oncogene driver, a tumour suppressor, a biomarker and a DNA repair gene, and an approved or late-stage drug is recorded against it. Tied to Renal cell carcinoma, Leukaemia, Non-Hodgkin lymphoma and 5 more."@en ;
  schema:url <https://onco.cc/targets/setd2/> ;
  schema:dateModified "2026-09-23"^^xsd:date ;
  schema:citation <https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:18420>, <https://www.uniprot.org/uniprotkb/Q9BYW2/entry>, <https://www.ncbi.nlm.nih.gov/gene/29072>, <https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000181555> ;
  onco:tag "cancer-genes-wave" ;
  onco:targetClass "transcription" ;
  schema:sameAs <https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:18420>, <https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000181555>, <https://www.uniprot.org/uniprotkb/Q9BYW2/entry>, <https://www.ncbi.nlm.nih.gov/gene/29072> ;
  onco:related <https://onco.cc/collections/civic/>, <https://onco.cc/collections/open-targets/>, <https://onco.cc/collections/intogen/> ;
  onco:cancers <https://onco.cc/cancers/rcc/>, <https://onco.cc/cancers/leukaemia/>, <https://onco.cc/cancers/non-hodgkin-lymphoma/>, <https://onco.cc/cancers/pancreatic/>, <https://onco.cc/cancers/mesothelioma/>, <https://onco.cc/cancers/skin-cancer/>, <https://onco.cc/cancers/lung-cancer/>, <https://onco.cc/cancers/prostate/> ;
  onco:drugs <https://onco.cc/drugs/temsirolimus/> .