# OnCo record sf3b1-mutation (term). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)". Whole corpus: https://onco.cc/api/v1/onco.nt
@prefix schema: <https://schema.org/> .
@prefix onco: <https://onco.cc/ns#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .

<https://onco.cc/terms/sf3b1-mutation/>
  a schema:DefinedTerm ;
  onco:kind "term" ;
  schema:identifier "sf3b1-mutation" ;
  schema:name "SF3B1 mutation"@en ;
  schema:alternateName "SF3B1"@en, "SF3B1-mutated"@en, "SF3B1-mutant"@en, "SF3B1 K700E"@en, "splicing factor 3b subunit 1"@en, "MDS-SF3B1"@en, "MDS with ring sideroblasts"@en, "MDS-RS"@en, "ring sideroblasts"@en, "refractory anaemia with ring sideroblasts"@en, "RARS"@en, "RARS-T"@en, "MDS/MPN with ring sideroblasts and thrombocytosis"@en ;
  schema:description "SF3B1 is a splicing gene whose mutation makes the marrow produce red cells with iron-stuffed mitochondria (ring sideroblasts); in myelodysplastic syndrome it defines a low-risk subtype with anaemia that responds to luspatercept, whereas in CLL and uveal melanoma the same mutation has different, mostly adverse or delayed-relapse, meaning."@en ;
  schema:url <https://onco.cc/terms/sf3b1-mutation/> ;
  schema:dateModified "2026-09-17"^^xsd:date ;
  schema:sameAs <https://en.wikipedia.org/wiki/SF3B1> ;
  schema:citation <https://en.wikipedia.org/wiki/SF3B1> ;
  onco:related <https://onco.cc/terms/ipss-m-ipss-r/>, <https://onco.cc/drugs/luspatercept/>, <https://onco.cc/drugs/imetelstat/>, <https://onco.cc/terms/ngs/>, <https://onco.cc/terms/cll-ipi/>, <https://onco.cc/terms/uveal-melanoma-prognostic-markers/>, <https://onco.cc/terms/aml-myelodysplasia-related/> ;
  onco:cancers <https://onco.cc/cancers/mds-lower-risk/>, <https://onco.cc/cancers/cll/>, <https://onco.cc/cancers/uveal-melanoma/>, <https://onco.cc/cancers/mucosal-melanoma/>, <https://onco.cc/cancers/aml-secondary/>, <https://onco.cc/cancers/cmml/> .