# OnCo record shp2 (target). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)". Whole corpus: https://onco.cc/api/v1/onco.nt
@prefix schema: <https://schema.org/> .
@prefix onco: <https://onco.cc/ns#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .

<https://onco.cc/targets/shp2/>
  a schema:BioChemEntity ;
  onco:kind "target" ;
  schema:identifier "shp2" ;
  schema:name "SHP2 (PTPN11)"@en ;
  schema:alternateName "SHP-2"@en, "PTP2C"@en, "SH-PTP2"@en, "protein tyrosine phosphatase non-receptor type 11"@en, "PTPN11" ;
  schema:description "SHP2 is an enzyme that sits between growth-factor receptors and RAS and keeps the RAS signal flowing. Blocking it removes the route by which KRAS-driven tumours bounce back from a KRAS inhibitor, which is why SHP2 inhibitors are being paired with KRAS G12C drugs."@en ;
  schema:url <https://onco.cc/targets/shp2/> ;
  schema:dateModified "2026-09-22"^^xsd:date ;
  schema:citation <https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:9644>, <https://www.uniprot.org/uniprotkb/Q06124/entry>, <https://www.ncbi.nlm.nih.gov/gene/5781> ;
  onco:tag "wave5-target" ;
  onco:targetClass "enzyme" ;
  schema:sameAs <https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:9644>, <https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000179295>, <https://www.uniprot.org/uniprotkb/Q06124/entry>, <https://www.ncbi.nlm.nih.gov/gene/5781> ;
  onco:related <https://onco.cc/drugs/glecirasib/>, <https://onco.cc/drugs/garsorasib/>, <https://onco.cc/targets/kras/>, <https://onco.cc/drugs/octreotide-lanreotide/> ;
  onco:cancers <https://onco.cc/cancers/nsclc/>, <https://onco.cc/cancers/colorectal/>, <https://onco.cc/cancers/pancreatic/> ;
  onco:technologies <https://onco.cc/technologies/kras-inhibitors/>, <https://onco.cc/technologies/kinase-inhibitors/> ;
  onco:drugs <https://onco.cc/drugs/sitneprotafib/> ;
  onco:pathways <https://onco.cc/pathways/ras-mapk/>, <https://onco.cc/pathways/rtk-activation/>, <https://onco.cc/pathways/resistance-routes-map/>, <https://onco.cc/pathways/pd1-checkpoint/> .