# OnCo record signatera (drug). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)". Whole corpus: https://onco.cc/api/v1/onco.nt
@prefix schema: <https://schema.org/> .
@prefix onco: <https://onco.cc/ns#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .

<https://onco.cc/drugs/signatera/>
  a schema:Drug ;
  onco:kind "drug" ;
  schema:identifier "signatera" ;
  schema:name "Signatera"@en ;
  schema:description "Signatera is Natera's tumour-informed blood test that tracks 16 mutations from each patient's own tumour to detect residual or returning cancer after surgery. Medicare covers it in colorectal, breast, bladder, lung and ovarian cancer and for immunotherapy monitoring, and in 2026 it selected the bladder cancer patients for the first approval based on circulating tumour DNA."@en ;
  schema:url <https://onco.cc/drugs/signatera/> ;
  schema:dateModified "2026-09-04"^^xsd:date ;
  schema:citation <https://clinicaltrials.gov/study/NCT04660344> ;
  onco:status "established" ;
  onco:modality "Tumour-informed ctDNA MRD test" ;
  onco:cancers <https://onco.cc/cancers/colorectal/>, <https://onco.cc/cancers/urothelial/>, <https://onco.cc/cancers/tnbc/>, <https://onco.cc/cancers/nsclc/>, <https://onco.cc/cancers/pancreatic/> ;
  onco:technologies <https://onco.cc/technologies/mrd-testing/>, <https://onco.cc/technologies/liquid-biopsy/> ;
  onco:companies <https://onco.cc/companies/natera/> ;
  onco:trials <https://onco.cc/trials/imvigor011/>, <https://onco.cc/trials/dynamic-iii/>, <https://onco.cc/trials/altair/> ;
  onco:keyPapers <https://onco.cc/key-papers/paper-magbanua-ispy2-ctdna-neoadjuvant-ann-oncol-2021/>, <https://onco.cc/key-papers/paper-lee-ctdna-adjuvant-benefit-localized-pancreatic-ann-oncol-2019/>, <https://onco.cc/key-papers/paper-groot-kras-ctdna-clinical-test-resected-pancreatic-ccr-2019/>, <https://onco.cc/key-papers/paper-reinert-ctdna-ultradeep-sequencing-colorectal-jama-oncol-2019/>, <https://onco.cc/key-papers/paper-henriksen-ctdna-stage-iii-colorectal-improve-it-ccr-2022/>, <https://onco.cc/key-papers/paper-galaxy-signatera-nat-med-2023/> .