# OnCo record single-arm (term). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)". Whole corpus: https://onco.cc/api/v1/onco.nt
@prefix schema: <https://schema.org/> .
@prefix onco: <https://onco.cc/ns#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .

<https://onco.cc/terms/single-arm/>
  a schema:DefinedTerm ;
  onco:kind "term" ;
  schema:identifier "single-arm" ;
  schema:name "Single-arm trial"@en ;
  schema:alternateName "single-arm"@en, "single arm"@en, "single-arm trial"@en, "single-arm phase 2"@en, "single-arm study"@en, "uncontrolled"@en, "non-randomised"@en, "nonrandomized"@en, "non-randomized"@en, "one-arm"@en, "open-label single-arm"@en, "basket cohort"@en, "expansion cohort"@en, "phase 2 cohort"@en, "expansion cohorts"@en, "single-arm studies"@en, "single-arm trials"@en ;
  schema:description "A trial where everyone gets the new drug and there is no comparison group; success is judged by the share of tumours that shrink and for how long. Fast and small, it underpinned accelerated approvals for larotrectinib, sotorasib, tarlatamab and most CAR-T products, but it cannot show that patients live longer."@en ;
  schema:url <https://onco.cc/terms/single-arm/> ;
  schema:dateModified "2026-09-09"^^xsd:date ;
  schema:sameAs <https://en.wikipedia.org/wiki/Single-arm_study_design> ;
  schema:citation <https://www.fda.gov/regulatory-information/search-fda-guidance-documents/clinical-trial-considerations-support-accelerated-approval-oncology-therapeutics> ;
  onco:related <https://onco.cc/terms/orr/>, <https://onco.cc/terms/duration-of-response-term/>, <https://onco.cc/terms/external-control-arm/>, <https://onco.cc/terms/accelerated-approval/>, <https://onco.cc/terms/basket-umbrella-platform/>, <https://onco.cc/terms/basket-trial/>, <https://onco.cc/terms/trial-failure-modes/>, <https://onco.cc/terms/clinical-equipoise/>, <https://onco.cc/terms/surrogate-validation/> ;
  onco:sections <https://onco.cc/fronts/drug-discovery/> ;
  onco:trials <https://onco.cc/trials/navigate/>, <https://onco.cc/trials/l-mind/>, <https://onco.cc/trials/roar-atc/>, <https://onco.cc/trials/arrow-thyroid/>, <https://onco.cc/trials/nmtrc003/>, <https://onco.cc/trials/pathfinder-2/> .