# OnCo record siopel-4 (trial). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)". Whole corpus: https://onco.cc/api/v1/onco.nt
@prefix schema: <https://schema.org/> .
@prefix onco: <https://onco.cc/ns#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .

<https://onco.cc/trials/siopel-4/>
  a schema:MedicalTrial ;
  onco:kind "trial" ;
  schema:identifier "siopel-4", "NCT00077389" ;
  schema:name "SIOPEL-4"@en ;
  schema:alternateName "SIOPEL 4"@en, "SIOPEL4"@en, "SIOP-SIOPEL-4"@en ;
  schema:description "SIOPEL-4 showed that giving cisplatin every week in a dense schedule, with doxorubicin, to children with high-risk hepatoblastoma got nearly all of them to respond and three quarters to complete resection, lifting three-year survival to 83 percent in a group that used to do poorly."@en ;
  schema:url <https://onco.cc/trials/siopel-4/> ;
  schema:dateModified "2026-09-22"^^xsd:date ;
  schema:citation <https://clinicaltrials.gov/study/NCT00077389> ;
  onco:status "positive" ;
  onco:tag "soc-trials" ;
  onco:phase "2" ;
  onco:cancers <https://onco.cc/cancers/hepatoblastoma/>, <https://onco.cc/cancers/childhood-cancers/> ;
  onco:technologies <https://onco.cc/technologies/cytotoxic-chemotherapy/> ;
  onco:drugs <https://onco.cc/drugs/cisplatin/>, <https://onco.cc/drugs/doxorubicin/>, <https://onco.cc/drugs/carboplatin/> ;
  onco:keyPapers <https://onco.cc/key-papers/paper-siopel-4-dose-dense-cisplatin-high-risk-hepatoblastoma-zsiros-lancet-oncol-2013/> .