# OnCo record small-molecule-api-synthesis (technology). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)". Whole corpus: https://onco.cc/api/v1/onco.nt
@prefix schema: <https://schema.org/> .
@prefix onco: <https://onco.cc/ns#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .

<https://onco.cc/technologies/small-molecule-api-synthesis/>
  a schema:MedicalTherapy ;
  onco:kind "technology" ;
  schema:identifier "small-molecule-api-synthesis" ;
  schema:name "Small-molecule API synthesis"@en ;
  schema:description "Before a tablet or a vial exists, the active drug itself has to be made: many chemical steps in reactors, or extraction from a plant, at a handful of factories most patients never hear of. When one of those factories stops, whole cancer drugs disappear."@en ;
  schema:url <https://onco.cc/technologies/small-molecule-api-synthesis/> ;
  schema:dateModified "2026-09-17"^^xsd:date ;
  schema:citation <https://www.ich.org/page/quality-guidelines>, <https://www.fda.gov/drugs/drug-shortages/report-drug-shortages-root-causes-and-potential-solutions>, <https://en.wikipedia.org/wiki/Active_ingredient> ;
  onco:status "standard-of-care" ;
  onco:tag "manufacturing-wave" ;
  onco:sections <https://onco.cc/fronts/chemotherapy/>, <https://onco.cc/fronts/targeted-therapy/>, <https://onco.cc/fronts/drug-discovery/> ;
  onco:technologies <https://onco.cc/technologies/oral-solid-dose-manufacturing/>, <https://onco.cc/technologies/sterile-injectable-generics-manufacturing/>, <https://onco.cc/technologies/high-potency-payload-synthesis/>, <https://onco.cc/technologies/pharmaceutical-gmp-inspections/>, <https://onco.cc/technologies/generic-drug-shortage-response/>, <https://onco.cc/technologies/cytotoxic-chemotherapy/>, <https://onco.cc/technologies/kinase-inhibitors/> ;
  onco:drugs <https://onco.cc/drugs/cisplatin/>, <https://onco.cc/drugs/carboplatin/>, <https://onco.cc/drugs/oxaliplatin/>, <https://onco.cc/drugs/paclitaxel/>, <https://onco.cc/drugs/vincristine/>, <https://onco.cc/drugs/imatinib/>, <https://onco.cc/drugs/methotrexate/>, <https://onco.cc/drugs/fluorouracil/> ;
  onco:companies <https://onco.cc/companies/wuxi-apptec/>, <https://onco.cc/companies/lonza/>, <https://onco.cc/companies/sterling-pharma-solutions/>, <https://onco.cc/companies/thermo-fisher/>, <https://onco.cc/companies/dr-reddys/>, <https://onco.cc/companies/sun-pharma/>, <https://onco.cc/companies/cipla/>, <https://onco.cc/companies/teva/> ;
  onco:bottlenecks <https://onco.cc/bottlenecks/b-drug-pricing/> .