# OnCo record smart-design (term). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)". Whole corpus: https://onco.cc/api/v1/onco.nt
@prefix schema: <https://schema.org/> .
@prefix onco: <https://onco.cc/ns#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .

<https://onco.cc/terms/smart-design/>
  a schema:DefinedTerm ;
  onco:kind "term" ;
  schema:identifier "smart-design" ;
  schema:name "SMART design (sequential multiple assignment randomised trial)"@en ;
  schema:alternateName "SMART"@en, "SMART design"@en, "SMART trial"@en, "sequential multiple assignment randomised trial"@en, "sequential multiple assignment randomized trial"@en, "adaptive treatment strategy"@en, "adaptive treatment strategies"@en, "dynamic treatment regime"@en, "dynamic treatment regimes"@en, "re-randomised"@en, "re-randomized"@en, "re-randomisation"@en, "second randomisation"@en, "response-guided strategy"@en, "strategy trial"@en, "treatment sequence trial"@en ;
  schema:description "A SMART trial randomises patients once at the start and again at a decision point, such as after the first scan or a residual disease test, to compare whole treatment strategies rather than single drugs."@en ;
  schema:url <https://onco.cc/terms/smart-design/> ;
  schema:dateModified "2026-09-17"^^xsd:date ;
  schema:sameAs <https://en.wikipedia.org/wiki/Adaptive_design_(medicine)> ;
  schema:citation <https://en.wikipedia.org/wiki/Adaptive_design_(medicine)>, <https://www.ich.org/page/efficacy-guidelines> ;
  onco:related <https://onco.cc/terms/seamless-adaptive/>, <https://onco.cc/terms/de-escalation/>, <https://onco.cc/terms/mrd/>, <https://onco.cc/terms/randomised-trial/>, <https://onco.cc/terms/biomarker-stratified-design/>, <https://onco.cc/terms/response-adaptive-randomisation/> ;
  onco:sections <https://onco.cc/fronts/drug-discovery/> ;
  onco:trials <https://onco.cc/trials/captivate/>, <https://onco.cc/trials/perseus/>, <https://onco.cc/trials/imvigor011/>, <https://onco.cc/trials/dynamic/> ;
  onco:bottlenecks <https://onco.cc/bottlenecks/b-trial-design/> .