# OnCo record smile-enktl (trial). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)". Whole corpus: https://onco.cc/api/v1/onco.nt
@prefix schema: <https://schema.org/> .
@prefix onco: <https://onco.cc/ns#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .

<https://onco.cc/trials/smile-enktl/>
  a schema:MedicalTrial ;
  onco:kind "trial" ;
  schema:identifier "smile-enktl" ;
  schema:name "SMILE"@en ;
  schema:alternateName "SMILE regimen"@en, "SMILE chemotherapy for extranodal NK/T-cell lymphoma"@en ;
  schema:description "An asparaginase-based regimen gave a response in four out of five people with an aggressive nasal lymphoma that had always resisted standard chemotherapy, and nearly all of them had dangerously low white cell counts."@en ;
  schema:url <https://onco.cc/trials/smile-enktl/> ;
  schema:dateModified "2026-10-01"^^xsd:date ;
  schema:citation <https://doi.org/10.1200/JCO.2011.35.6287> ;
  onco:status "positive" ;
  onco:tag "lymphoma-evidence" ;
  onco:phase "2" ;
  onco:cancers <https://onco.cc/cancers/peripheral-t-cell-lymphoma/>, <https://onco.cc/cancers/non-hodgkin-lymphoma/> ;
  onco:sections <https://onco.cc/fronts/chemotherapy/> ;
  onco:drugs <https://onco.cc/drugs/dexamethasone/>, <https://onco.cc/drugs/methotrexate/>, <https://onco.cc/drugs/ifosfamide/>, <https://onco.cc/drugs/asparaginase/>, <https://onco.cc/drugs/etoposide/> ;
  onco:terms <https://onco.cc/terms/orr/>, <https://onco.cc/terms/complete-response/>, <https://onco.cc/terms/autologous-transplant/> ;
  onco:bottlenecks <https://onco.cc/bottlenecks/b-rare-cancers/>, <https://onco.cc/bottlenecks/b-global-access/> ;
  onco:keyPapers <https://onco.cc/key-papers/paper-smile-chemotherapy-nk-t-cell-lymphoma-jco-2011/> .