# OnCo record smoothened (target). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)". Whole corpus: https://onco.cc/api/v1/onco.nt
@prefix schema: <https://schema.org/> .
@prefix onco: <https://onco.cc/ns#> .
@prefix owl: <http://www.w3.org/2002/07/owl#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .

<https://onco.cc/targets/smoothened/>
  a schema:BioChemEntity ;
  onco:kind "target" ;
  schema:identifier "smoothened" ;
  schema:name "Smoothened (hedgehog pathway)"@en ;
  schema:description "The switch in the hedgehog developmental pathway that is stuck on in basal cell carcinoma and some medulloblastomas; three approved pills block it."@en ;
  schema:url <https://onco.cc/targets/smoothened/> ;
  schema:dateModified "2026-09-08"^^xsd:date ;
  schema:sameAs <https://en.wikipedia.org/wiki/Smoothened>, <https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:11119>, <https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000128602>, <https://www.uniprot.org/uniprotkb/Q99835/entry>, <https://www.ncbi.nlm.nih.gov/gene/6608> ;
  owl:sameAs <http://www.wikidata.org/entity/Q18031607> ;
  schema:citation <https://doi.org/10.1038/ng.3525> ;
  onco:tag "gap-fill" ;
  schema:alternateName "SMO" ;
  onco:targetClass "other" ;
  onco:firstDescribed "1996"^^xsd:gYear ;
  onco:cancers <https://onco.cc/cancers/basal-cell-carcinoma/>, <https://onco.cc/cancers/medulloblastoma/>, <https://onco.cc/cancers/aml/> ;
  onco:technologies <https://onco.cc/technologies/kinase-inhibitors/> ;
  onco:drugs <https://onco.cc/drugs/vismodegib/>, <https://onco.cc/drugs/sonidegib/>, <https://onco.cc/drugs/glasdegib/> ;
  onco:pathways <https://onco.cc/pathways/basal-cell-carcinoma-signalling/> ;
  onco:keyPapers <https://onco.cc/key-papers/paper-bonilla-nat-genet/> .