# OnCo record sn-38 (term). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)". Whole corpus: https://onco.cc/api/v1/onco.nt
@prefix schema: <https://schema.org/> .
@prefix onco: <https://onco.cc/ns#> .
@prefix owl: <http://www.w3.org/2002/07/owl#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .

<https://onco.cc/terms/sn-38/>
  a schema:DefinedTerm ;
  onco:kind "term" ;
  schema:identifier "sn-38" ;
  schema:name "SN-38"@en ;
  schema:alternateName "7-ethyl-10-hydroxycamptothecin"@en ;
  schema:description "SN-38 is the active form of the chemotherapy irinotecan and the payload of sacituzumab govitecan. It blocks topoisomerase I so DNA breaks during copying, but it kills cells only at nanomolar concentrations, so the ADC carries roughly eight copies per antibody and uses a linker that releases it in the tumour; slow metabolisers (UGT1A1*28) get more diarrhoea."@en ;
  schema:url <https://onco.cc/terms/sn-38/> ;
  schema:dateModified "2026-09-09"^^xsd:date ;
  schema:sameAs <https://en.wikipedia.org/wiki/SN-38> ;
  owl:sameAs <http://www.wikidata.org/entity/Q1750127> ;
  schema:citation <https://en.wikipedia.org/wiki/SN-38> ;
  onco:related <https://onco.cc/technologies/topoisomerase-inhibitors/>, <https://onco.cc/terms/efflux-pump/>, <https://onco.cc/drugs/irinotecan/> ;
  onco:technologies <https://onco.cc/technologies/adc/> ;
  onco:drugs <https://onco.cc/drugs/sacituzumab-govitecan/> ;
  onco:terms <https://onco.cc/terms/payload/>, <https://onco.cc/terms/topoisomerase-i-payloads/> .