# OnCo record solar-1 (trial). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)". Whole corpus: https://onco.cc/api/v1/onco.nt
@prefix schema: <https://schema.org/> .
@prefix onco: <https://onco.cc/ns#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .

<https://onco.cc/trials/solar-1/>
  a schema:MedicalTrial ;
  onco:kind "trial" ;
  schema:identifier "solar-1", "NCT02437318" ;
  schema:name "SOLAR-1"@en ;
  schema:description "The first trial to show a PI3K inhibitor helps in breast cancers carrying a PIK3CA mutation, at the cost of high blood sugar and rash."@en ;
  schema:url <https://onco.cc/trials/solar-1/> ;
  schema:dateModified "2026-09-07"^^xsd:date ;
  schema:citation <https://clinicaltrials.gov/study/NCT02437318> ;
  onco:status "positive" ;
  onco:phase "3" ;
  schema:startDate "2015-07-23" ;
  onco:cancers <https://onco.cc/cancers/breast-hr-positive/>, <https://onco.cc/cancers/hr-positive-metastatic-post-cdk46/> ;
  onco:technologies <https://onco.cc/technologies/kinase-inhibitors/>, <https://onco.cc/technologies/pi3k-akt-mtor-inhibitors/> ;
  onco:targets <https://onco.cc/targets/pik3ca/> ;
  onco:drugs <https://onco.cc/drugs/alpelisib/> ;
  onco:companies <https://onco.cc/companies/novartis/> ;
  onco:people <https://onco.cc/people/fabrice-andre/> ;
  onco:keyPapers <https://onco.cc/key-papers/paper-solar-1-alpelisib-nejm-2019/>, <https://onco.cc/key-papers/paper-solar-1-ann-oncol-2021-update/> .