# OnCo record sonrotoclax (drug). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)". Whole corpus: https://onco.cc/api/v1/onco.nt
@prefix schema: <https://schema.org/> .
@prefix onco: <https://onco.cc/ns#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .

<https://onco.cc/drugs/sonrotoclax/>
  a schema:Drug ;
  onco:kind "drug" ;
  schema:identifier "sonrotoclax" ;
  schema:name "Sonrotoclax"@en ;
  schema:description "Sonrotoclax is a more potent, shorter-acting successor to venetoclax. It was approved for mantle cell lymphoma in May 2026 and is in late-stage trials with zanubrutinib for CLL."@en ;
  schema:url <https://onco.cc/drugs/sonrotoclax/> ;
  schema:dateModified "2026-09-07"^^xsd:date ;
  schema:citation <https://dailymed.nlm.nih.gov/dailymed/search.cfm?query=Sonrotoclax> ;
  onco:status "approved" ;
  onco:modality "Small-molecule BCL-2 inhibitor (second generation)" ;
  schema:alternateName "Beqalzi" ;
  onco:approval "China 2025: Relapsed/refractory MCL and CLL/SLL after BTK inhibitor", "US 2026: Relapsed/refractory mantle cell lymphoma after ≥2 lines including a BTK inhibitor (accelerated)" ;
  onco:acceleratedApproval "US 2026-05-13: Treatment of adult patients with relapsed or refractory mantle cell lymphoma (MCL) after at least two lines of systemic therapy, including a Bruton’s tyrosine kinase (BTK) inhibitor." ;
  onco:related <https://onco.cc/drugs/venetoclax/> ;
  onco:cancers <https://onco.cc/cancers/cll/>, <https://onco.cc/cancers/dlbcl/> ;
  onco:technologies <https://onco.cc/technologies/kinase-inhibitors/>, <https://onco.cc/technologies/bcl2-inhibitors/> ;
  onco:targets <https://onco.cc/targets/bcl2/> ;
  onco:companies <https://onco.cc/companies/beone/> ;
  onco:pathways <https://onco.cc/pathways/apoptosis-bcl2/> ;
  onco:terms <https://onco.cc/terms/tumor-lysis-syndrome/> ;
  onco:trials <https://onco.cc/trials/celestial-tncll/>, <https://onco.cc/trials/nct06742996/>, <https://onco.cc/trials/nct06697184/>, <https://onco.cc/trials/nct05471843/>, <https://onco.cc/trials/nct04973605/>, <https://onco.cc/trials/nct06943872/>, <https://onco.cc/trials/nct04771130/>, <https://onco.cc/trials/nct07277231/>, <https://onco.cc/trials/nct05479994/>, <https://onco.cc/trials/nct06634589/>, <https://onco.cc/trials/nct06637501/>, <https://onco.cc/trials/nct05952037/> .