# OnCo record spen (target). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)". Whole corpus: https://onco.cc/api/v1/onco.nt
@prefix schema: <https://schema.org/> .
@prefix onco: <https://onco.cc/ns#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .

<https://onco.cc/targets/spen/>
  a schema:BioChemEntity ;
  onco:kind "target" ;
  schema:identifier "spen" ;
  schema:name "SPEN"@en ;
  schema:alternateName "spen family transcriptional repressor"@en, "Msx2-interacting protein"@en, "KIAA0929"@en, "SHARP"@en, "RBM15C"@en, "SPEN" ;
  schema:description "SPEN (Msx2-interacting protein) is a protein that switches other genes on and off. The public catalogues list it as an oncogene driver, a tumour suppressor and a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Breast cancer, Non-Hodgkin lymphoma, Renal cell carcinoma and 5 more."@en ;
  schema:url <https://onco.cc/targets/spen/> ;
  schema:dateModified "2026-09-23"^^xsd:date ;
  schema:citation <https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:17575>, <https://www.uniprot.org/uniprotkb/Q96T58/entry>, <https://www.ncbi.nlm.nih.gov/gene/23013>, <https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000065526> ;
  onco:tag "cancer-genes-wave" ;
  onco:targetClass "transcription" ;
  schema:sameAs <https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:17575>, <https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000065526>, <https://www.uniprot.org/uniprotkb/Q96T58/entry>, <https://www.ncbi.nlm.nih.gov/gene/23013> ;
  onco:related <https://onco.cc/collections/civic/>, <https://onco.cc/collections/open-targets/>, <https://onco.cc/collections/intogen/> ;
  onco:cancers <https://onco.cc/cancers/breast-cancer/>, <https://onco.cc/cancers/non-hodgkin-lymphoma/>, <https://onco.cc/cancers/rcc/>, <https://onco.cc/cancers/cervical/>, <https://onco.cc/cancers/nasopharyngeal/>, <https://onco.cc/cancers/prostate/>, <https://onco.cc/cancers/salivary-gland/>, <https://onco.cc/cancers/skin-cancer/> .