# OnCo record spop-mutation (biomarker). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)". Whole corpus: https://onco.cc/api/v1/onco.nt
@prefix schema: <https://schema.org/> .
@prefix onco: <https://onco.cc/ns#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .

<https://onco.cc/biomarkers/spop-mutation/>
  a schema:MedicalTest ;
  onco:kind "biomarker" ;
  schema:identifier "spop-mutation" ;
  schema:name "SPOP mutation"@en ;
  schema:alternateName "SPOP"@en, "SPOP mutant"@en, "SPOP F133L"@en, "SPOP mutation"@en, "speckle-type POZ protein mutation"@en ;
  schema:description "The commonest single point mutation in prostate cancer, in about one tumour in eight. Tumours carrying it never have the usual ERG fusion, and men whose metastatic disease carries it tend to stay hormone-sensitive for longer."@en ;
  schema:url <https://onco.cc/biomarkers/spop-mutation/> ;
  schema:dateModified "2026-09-25"^^xsd:date ;
  schema:citation <https://doi.org/10.1038/ng.2279>, <https://doi.org/10.1158/1078-0432.CCR-20-0168>, <https://www.cbioportal.org/study/summary?id=prostate_msk_2024> ;
  onco:tag "biomarker", "prostate" ;
  onco:related <https://onco.cc/biomarkers/tmprss2-erg-fusion/> ;
  onco:cancers <https://onco.cc/cancers/prostate/>, <https://onco.cc/cancers/prostate-mhspc/> ;
  onco:technologies <https://onco.cc/technologies/cgp/> ;
  onco:targets <https://onco.cc/targets/spop/>, <https://onco.cc/targets/androgen-receptor/> ;
  onco:pathways <https://onco.cc/pathways/ubiquitin-proteasome-system/>, <https://onco.cc/pathways/ar-signaling/>, <https://onco.cc/pathways/prostate-cancer-signalling/> ;
  onco:terms <https://onco.cc/terms/driver-mutation/>, <https://onco.cc/terms/gene-fusion/>, <https://onco.cc/terms/castration-resistance/>, <https://onco.cc/terms/mcrpc-mhspc/> ;
  onco:keyPapers <https://onco.cc/key-papers/paper-barbieri-spop-foxa1-med12-prostate-nat-genet-2012/>, <https://onco.cc/key-papers/paper-tcga-molecular-taxonomy-primary-prostate-cell-2015/>, <https://onco.cc/key-papers/paper-stopsack-mcspc-genomic-alterations-outcomes-ccr-2020/> .