# OnCo record srd5a2 (target). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)". Whole corpus: https://onco.cc/api/v1/onco.nt
@prefix schema: <https://schema.org/> .
@prefix onco: <https://onco.cc/ns#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .

<https://onco.cc/targets/srd5a2/>
  a schema:BioChemEntity ;
  onco:kind "target" ;
  schema:identifier "srd5a2" ;
  schema:name "5-alpha-reductase type 2 (SRD5A2)"@en ;
  schema:description "5-alpha-reductase turns testosterone into the more potent dihydrotestosterone inside the prostate; finasteride and dutasteride block it, and two large trials showed they cut prostate cancer diagnoses by about a quarter while raising concern about high-grade tumours."@en ;
  schema:url <https://onco.cc/targets/srd5a2/> ;
  schema:dateModified "2026-09-04"^^xsd:date ;
  schema:sameAs <https://en.wikipedia.org/wiki/SRD5A2>, <https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:11285>, <https://www.ensembl.org/Homo_sapiens/Gene/Summary?g=ENSG00000277893>, <https://www.uniprot.org/uniprotkb/P31213/entry>, <https://www.ncbi.nlm.nih.gov/gene/6716> ;
  schema:citation <https://www.uniprot.org/uniprotkb/P31213/entry>, <https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:11285>, <https://www.ebi.ac.uk/chembl/explore/target/CHEMBL1856> ;
  onco:tag "chembl-gap" ;
  schema:alternateName "SRD5A2" ;
  onco:targetClass "enzyme" ;
  onco:firstDescribed "1991"^^xsd:gYear ;
  onco:related <https://onco.cc/targets/androgen-receptor/>, <https://onco.cc/targets/cyp17a1/> ;
  onco:cancers <https://onco.cc/cancers/prostate/> ;
  onco:drugs <https://onco.cc/drugs/abiraterone/> .