# OnCo record stat5 (target). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)". Whole corpus: https://onco.cc/api/v1/onco.nt
@prefix schema: <https://schema.org/> .
@prefix onco: <https://onco.cc/ns#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .

<https://onco.cc/targets/stat5/>
  a schema:BioChemEntity ;
  onco:kind "target" ;
  schema:identifier "stat5" ;
  schema:name "STAT5 (STAT5A, STAT5B)"@en ;
  schema:alternateName "STAT5A"@en, "STAT5B"@en, "signal transducer and activator of transcription 5"@en, "STAT5A, STAT5B" ;
  schema:description "STAT5 is the messenger that carries growth signals from FLT3, JAK2 and BCR::ABL1 into the nucleus and switches on survival genes in leukaemia cells. No drug hits STAT5 directly yet; the FLT3 and ABL inhibitors work by cutting off the signal above it."@en ;
  schema:url <https://onco.cc/targets/stat5/> ;
  schema:dateModified "2026-09-22"^^xsd:date ;
  schema:citation <https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:11366>, <https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:11367>, <https://www.uniprot.org/uniprotkb/P42229/entry>, <https://www.uniprot.org/uniprotkb/P51692/entry>, <https://www.ncbi.nlm.nih.gov/gene/6776>, <https://www.ncbi.nlm.nih.gov/gene/6777> ;
  onco:tag "wave5-target" ;
  onco:targetClass "transcription" ;
  onco:related <https://onco.cc/drugs/gilteritinib/>, <https://onco.cc/drugs/midostaurin/>, <https://onco.cc/drugs/quizartinib/>, <https://onco.cc/drugs/ponatinib/>, <https://onco.cc/targets/flt3/>, <https://onco.cc/targets/bcr-abl/>, <https://onco.cc/targets/jak2/>, <https://onco.cc/targets/mpl/> ;
  onco:cancers <https://onco.cc/cancers/aml/>, <https://onco.cc/cancers/aml-flt3/>, <https://onco.cc/cancers/all-leukemia/>, <https://onco.cc/cancers/cml-advanced-phase/> ;
  onco:pathways <https://onco.cc/pathways/jak-stat/>, <https://onco.cc/pathways/aml-signalling/>, <https://onco.cc/pathways/cml-signalling/>, <https://onco.cc/pathways/bcr-abl1-signalling/> .