# OnCo record swi-snf-chromatin (pathway). Data CC BY-NC 4.0, attribute "Data from OnCo (onco.cc)". Whole corpus: https://onco.cc/api/v1/onco.nt
@prefix schema: <https://schema.org/> .
@prefix onco: <https://onco.cc/ns#> .
@prefix owl: <http://www.w3.org/2002/07/owl#> .
@prefix xsd: <http://www.w3.org/2001/XMLSchema#> .

<https://onco.cc/pathways/swi-snf-chromatin/>
  a schema:BioChemEntity ;
  onco:kind "pathway" ;
  schema:identifier "swi-snf-chromatin" ;
  schema:name "SWI/SNF chromatin remodelling"@en ;
  schema:description "A machine that opens and closes DNA so genes can be read. One in five cancers has a broken part (ARID1A, SMARCA4, PBRM1), and losing one part often creates a dependence on its twin, which is the basis for new synthetic-lethal drugs."@en ;
  schema:url <https://onco.cc/pathways/swi-snf-chromatin/> ;
  schema:dateModified "2026-09-08"^^xsd:date ;
  schema:sameAs <https://en.wikipedia.org/wiki/SWI/SNF> ;
  owl:sameAs <http://www.wikidata.org/entity/Q21095139> ;
  schema:citation <https://doi.org/10.1016/j.tig.2020.07.011> ;
  onco:tag "mechanism" ;
  onco:cancers <https://onco.cc/cancers/rcc/>, <https://onco.cc/cancers/ovarian/>, <https://onco.cc/cancers/nsclc/>, <https://onco.cc/cancers/sarcoma/> ;
  onco:technologies <https://onco.cc/technologies/synthetic-lethality-approaches/>, <https://onco.cc/technologies/protac-degrader/> ;
  onco:targets <https://onco.cc/targets/ezh2/>, <https://onco.cc/targets/atr/> ;
  onco:institutions <https://onco.cc/institutions/dana-farber/>, <https://onco.cc/institutions/broad-institute/>, <https://onco.cc/institutions/stanford/> ;
  onco:pathways <https://onco.cc/pathways/epigenetic-reprogramming/>, <https://onco.cc/pathways/cancer-stem-cells-plasticity/>, <https://onco.cc/pathways/replication-stress/> ;
  onco:keyPapers <https://onco.cc/key-papers/paper-centore-trends-genet/> .